Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Division of Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital and Institute, Beijing, China.
Department of Medical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Epigenetics. 2021 Aug;16(8):819-837. doi: 10.1080/15592294.2020.1827722. Epub 2020 Oct 19.
N6-methyladenosine (m6A), the most prevalent RNA internal modification, is present in most eukaryotic species and prokaryotes. Studies have highlighted an intricate network architecture by which m6A epitranscriptome impacts on immune response and function. However, it was only until recently that the mechanisms underlying the involvement of m6A modification in immune system were uncovered. Here, we systematically review the m6A involvement in the regulation of innate and adaptive immune cells. Further, the interplay between m6A modification and anti-inflammatory, anti-viral and anti-tumour immunity is also comprehensively summarized. Finally, we focus on the future prospects of m6A modification in immune modulation. A better understanding of the crosstalk between m6A modification and immune system is of great significance to reveal new pathogenic pathways and to develop promising therapeutic targets of diseases.
N6-甲基腺苷（m6A）是最常见的 RNA 内部修饰，存在于大多数真核生物和原核生物中。研究强调了 m6A 转录组通过何种复杂的网络结构来影响免疫反应和功能。然而，直到最近，人们才揭示了 m6A 修饰参与免疫系统的机制。在这里，我们系统地回顾了 m6A 修饰在调节先天和适应性免疫细胞中的作用。此外，我们还全面总结了 m6A 修饰与抗炎、抗病毒和抗肿瘤免疫之间的相互作用。最后，我们关注 m6A 修饰在免疫调节中的未来前景。更好地理解 m6A 修饰与免疫系统之间的相互作用对于揭示新的发病途径和开发疾病有前途的治疗靶点具有重要意义。
