College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China.
Bioengineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Anal Sci. 2021 Mar 10;37(3):415-419. doi: 10.2116/analsci.20SCR02. Epub 2020 Oct 16.
Anisotropic gold nanoparticles have attracted great interest due to their unique physicochemical properties derived from the shape anisotropy. Manipulation of their interfacial interactions, and thereby the assembling behaviors are often requisite in their applications ranging from optical sensing and diagnosis to self-assembly. Recently, the control of interfacial force based on base pair stacking of DNA terminals have offered a new avenue to surface engineering of nanostructures. In this review, we focus on the DNA base stacking-induced assembly of anisotropic gold nanoparticles, such as nanorods and nanotriangles. The fundamental aspects of anisotropic gold nanoparticles are provided, including the mechanism of the anisotropic growth, the properties arising from the anisotropic shape, and the construction of DNA-grafted anisotropic gold nanoparticles. Then, the advanced applications of their functional assemblies in biosensing and ordered assembly are summarized, followed by a comparison with gold nanospheres. Finally, conclusions and the direction of outlooks are given including future challenges and opportunities in this field.
各向异性金纳米粒子因其形状各向异性带来的独特物理化学性质而引起了极大的关注。在从光学传感和诊断到自组装的各种应用中，通常需要操纵其界面相互作用，从而控制其组装行为。最近，基于 DNA 末端碱基堆积的界面力控制为纳米结构的表面工程提供了新途径。在这篇综述中，我们重点介绍了基于 DNA 碱基堆积诱导的各向异性金纳米粒子（如纳米棒和纳米三角形）的组装。提供了各向异性金纳米粒子的基本方面，包括各向异性生长的机制、各向异性形状产生的性质以及 DNA 接枝各向异性金纳米粒子的构建。然后，总结了它们功能组装在生物传感和有序组装中的高级应用，并与金纳米球进行了比较。最后，给出了结论和展望，包括该领域未来的挑战和机遇。
