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多组分反应:“轻松搞定”。

Multicomponent Reactions: "Kinderleicht".

作者信息

Neochoritis Constantinos G, Zarganes-Tzitzikas Tryfon, Katsampoxaki-Hodgetts Kallia, Dömling Alexander

机构信息

Drug Design Group, Department of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen 9700 AV, The Netherlands.

Department of Chemistry, University of Crete, 70013 Heraklion, Greece.

出版信息

J Chem Educ. 2020 Oct 13;97(10):3739-3745. doi: 10.1021/acs.jchemed.0c00290. Epub 2020 Aug 31.

Abstract

A demonstration experiment of the synthesis of a novel tetrazole derivative via a multicomponent reaction (Ugi tetrazole four component reaction, UT-4CR) bearing a luminol moiety and a subsequent exploitation of its chemiluminescent properties is described. A complex product is generated in just one simple step, so simple that children can do it: "kinderleicht", German for dead easy. Students are stimulated, inspired, and involved in a multilevel active learning process using the Steps to Inquiry framework as a metacognitive tool that raises student awareness regarding scientific process and prompts them to ask their own questions discussing the merits of a mechanism and evaluating its effectiveness before they start their own cycles of inquiry.

摘要

描述了通过多组分反应(乌吉四氮唑四组分反应,UT-4CR)合成一种带有鲁米诺部分的新型四氮唑衍生物的演示实验,以及对其化学发光性质的后续研究。只需一个简单步骤就能生成一种复杂产物,这个步骤简单到孩子们都能操作:“kinderleicht”,德语,意为极其容易。学生们会受到激励、启发,并参与到一个多层次的主动学习过程中,该过程使用探究步骤框架作为一种元认知工具,提高学生对科学过程的认识,并促使他们在开始自己的探究循环之前,提出自己的问题,讨论一种机制的优点并评估其有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a75c/7558297/fee529b4f004/ed0c00290_0004.jpg

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