Neochoritis Constantinos G, Zarganes-Tzitzikas Tryfon, Katsampoxaki-Hodgetts Kallia, Dömling Alexander
Drug Design Group, Department of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen 9700 AV, The Netherlands.
Department of Chemistry, University of Crete, 70013 Heraklion, Greece.
J Chem Educ. 2020 Oct 13;97(10):3739-3745. doi: 10.1021/acs.jchemed.0c00290. Epub 2020 Aug 31.
A demonstration experiment of the synthesis of a novel tetrazole derivative via a multicomponent reaction (Ugi tetrazole four component reaction, UT-4CR) bearing a luminol moiety and a subsequent exploitation of its chemiluminescent properties is described. A complex product is generated in just one simple step, so simple that children can do it: "kinderleicht", German for dead easy. Students are stimulated, inspired, and involved in a multilevel active learning process using the Steps to Inquiry framework as a metacognitive tool that raises student awareness regarding scientific process and prompts them to ask their own questions discussing the merits of a mechanism and evaluating its effectiveness before they start their own cycles of inquiry.
描述了通过多组分反应(乌吉四氮唑四组分反应,UT-4CR)合成一种带有鲁米诺部分的新型四氮唑衍生物的演示实验,以及对其化学发光性质的后续研究。只需一个简单步骤就能生成一种复杂产物,这个步骤简单到孩子们都能操作:“kinderleicht”,德语,意为极其容易。学生们会受到激励、启发,并参与到一个多层次的主动学习过程中,该过程使用探究步骤框架作为一种元认知工具,提高学生对科学过程的认识,并促使他们在开始自己的探究循环之前,提出自己的问题,讨论一种机制的优点并评估其有效性。