Ageev A K
Vopr Onkol. 1987;33(8):27-33.
A clinico-anatomical evaluation of the evidence on 3436 autopsies (1091 cases of cancer included) was carried out. The levels of glucagon-producing A- and insulin-producing B-cells were studied in pancreatic islands from 148 autopsied cases (33 cases of cancer included). Diabetes mellitus incidence in non-tumor cases was thrice (13.73%) that in cancer patients older than 54 years (4.15%). However, pancreatic islands' A-cell levels were higher than those of B-cells in both groups, such prevalence being generally regarded as a causative factor of diabetes mellitus development. The study was concerned with incidence of diabetes mellitus in cases of different primary cancers, the significance of cachexia, corticosteroid production by cancers of the adrenal cortex and some other factors which influence clinical manifestations of diabetes mellitus, particularly, those related to age-linked changes in A/B-cells ratios in pancreatic islands.
对3436例尸检（包括1091例癌症病例）的证据进行了临床解剖学评估。在148例尸检病例（包括33例癌症病例）的胰岛中研究了产生胰高血糖素的A细胞和产生胰岛素的B细胞水平。非肿瘤病例中的糖尿病发病率是54岁以上癌症患者（4.15%）的三倍（13.73%）。然而，两组中胰岛的A细胞水平均高于B细胞水平，这种普遍情况通常被视为糖尿病发展的一个致病因素。该研究关注不同原发性癌症病例中的糖尿病发病率、恶病质的意义、肾上腺皮质癌产生的皮质类固醇以及其他一些影响糖尿病临床表现的因素，特别是那些与胰岛中A/B细胞比率的年龄相关变化有关的因素。
