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胰岛淀粉样变及其与糖尿病的关系(作者译)

[Amyloid of islets of Langerhans and its relation to diabetes mellitus (author's transl)].

作者信息

Schneider H M, Störkel S, Will W

出版信息

Dtsch Med Wochenschr. 1980 Aug 15;105(33):1143-7. doi: 10.1055/s-2008-1070828.

DOI:10.1055/s-2008-1070828
PMID:7004825
Abstract

After grading into 4 groups of severity the extent of amyloidosis of the islets of Langerhans was investigated in 60 patients with diabetes and in 60 without. Distinction of 3 stages of diabetes according to clinical parameters showed clear connections between the stage of diabetes and the extent of amyloidosis. Development of amyloid locally may be evidence for progressive B cell insufficiency in diabetes of adults.

摘要

在将60例糖尿病患者和60例非糖尿病患者的胰岛淀粉样变性程度分为4组严重程度后进行了研究。根据临床参数区分糖尿病的3个阶段显示,糖尿病阶段与淀粉样变性程度之间存在明显联系。局部淀粉样变的发生可能是成人糖尿病中进行性B细胞功能不全的证据。

相似文献

1
[Amyloid of islets of Langerhans and its relation to diabetes mellitus (author's transl)].胰岛淀粉样变及其与糖尿病的关系(作者译)
Dtsch Med Wochenschr. 1980 Aug 15;105(33):1143-7. doi: 10.1055/s-2008-1070828.
2
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Quantitative studies on amyloid in the islets of Langerhans.胰岛中淀粉样蛋白的定量研究。
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Lipids Health Dis. 2018 Mar 9;17(1):42. doi: 10.1186/s12944-018-0694-8.
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Human Islets Have Fewer Blood Vessels than Mouse Islets and the Density of Islet Vascular Structures Is Increased in Type 2 Diabetes.
与小鼠胰岛相比,人类胰岛的血管较少,并且在2型糖尿病中胰岛血管结构的密度会增加。
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Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels.多态性人胰岛淀粉样多肽(胰岛淀粉素)双孔道的非选择性离子通道活性。
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Diabetologia. 2012 Nov;55(11):2989-98. doi: 10.1007/s00125-012-2678-y. Epub 2012 Aug 17.
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Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?毒性寡聚物与胰岛β细胞死亡:关联定罪还是旁证定罪?
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Amyloidogenesis of natively unfolded proteins.天然未折叠蛋白的淀粉样变
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Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?胰岛淀粉样变:是胰岛功能障碍的并发症还是2型糖尿病的病因?
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