Ageev A K
Arkh Patol. 1986;48(5):11-5.
Pancreas was examined in 136 patients who died at the age of 7 to 89 years of various diseases including 22 with diabetes mellitus. Amyloidosis of its islands was observed in 9 patients (aged 49 and over); 6 out of them suffered from diabetes mellitus. Number of islands with amyloidosis and amyloid quantity were determined morphometrically. Glucagon-producing A-cells and insulin-producing B-cells in the islands not involved in amyloidosis were counted in sections impregnated by Grimelius. It is found that the development of diabetes is determined not only by the islands amyloidosis but by the quantitative domination of A-cells over B-cells in the islands without amyloidosis as well being the manifestation of aging processes.
对136例年龄在7至89岁因各种疾病死亡的患者的胰腺进行了检查，其中包括22例糖尿病患者。在9例患者（年龄在49岁及以上）中观察到胰岛淀粉样变性；其中6例患有糖尿病。采用形态计量学方法确定了发生淀粉样变性的胰岛数量和淀粉样蛋白量。在经格里米利厄斯染色的切片中，对未发生淀粉样变性的胰岛中产生胰高血糖素的A细胞和产生胰岛素的B细胞进行计数。结果发现，糖尿病的发生不仅取决于胰岛淀粉样变性，还取决于未发生淀粉样变性的胰岛中A细胞相对于B细胞的数量优势，这也是衰老过程的一种表现。
