Otting U, Eggert S, Eggert W, Zoellner K, Buchali K
Z Urol Nephrol. 1987 Jun;80(6):341-7.
For characterising the elimination and metabolisation performance of the liver in chronic renal insufficiency the galactose load test was carried out. 9 children with healthy liver and kidneys, 35 children with chronic renal insufficiency (15 were conservatively treated = group 1, 20 were in the chronic haemodialysis programme = group 2) as well as 5 children after kidney transplantation were examined. In group 1 a normal blood galactose concentration was present. Patients of the 2nd group showed increased concentrations of galactose in the blood which might refer to a decreased redox potential in the liver caused by the uraemic intoxication. In the group of patients who underwent a kidney transplantation in the patients with azathioprine therapy a disturbed use of galactose was present. Children with cyclosporin-A had a normal galactose concentration.
为了表征慢性肾功能不全患者肝脏的清除和代谢功能，进行了半乳糖负荷试验。对9名肝脏和肾脏健康的儿童、35名慢性肾功能不全儿童（15名接受保守治疗 = 第1组，20名接受慢性血液透析治疗 = 第2组）以及5名肾移植术后儿童进行了检查。第1组血液半乳糖浓度正常。第2组患者血液中半乳糖浓度升高，这可能是由于尿毒症中毒导致肝脏氧化还原电位降低所致。在接受硫唑嘌呤治疗的肾移植患者组中，半乳糖的利用出现紊乱。使用环孢素A的儿童半乳糖浓度正常。
