Zhang Yue, Qian Huizhu, He Jing, Gao Wen
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 China.
Biomark Res. 2020 Oct 15;8:52. doi: 10.1186/s40364-020-00233-0. eCollection 2020.
The tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are newly discovered noncoding RNAs in recent years. They are derived from specific cleavage of mature and pre-tRNAs and expressed in various cancers. They enhance cell proliferation and metastasis or inhibit cancer progression. Many studies have investigated their roles in the diagnosis, progression, metastasis, and prognosis of various cancers, but the mechanisms through which they are involved in resistance to cancer treatment are unclear. This review outlines the classification of tRFs and tiRNAs and their mechanisms in cancer drug resistance, thus providing new ideas for cancer treatment.
转运RNA衍生片段（tRFs）和半转运RNA（tiRNAs）是近年来新发现的非编码RNA。它们来源于成熟和前体转运RNA的特异性切割，并在多种癌症中表达。它们可促进细胞增殖和转移或抑制癌症进展。许多研究调查了它们在各种癌症的诊断、进展、转移和预后中的作用，但它们参与癌症治疗耐药性的机制尚不清楚。本综述概述了tRFs和tiRNAs的分类及其在癌症耐药性中的机制，从而为癌症治疗提供新思路。
