Zayet S, Klopfenstein T, Mezher C, Gendrin V, Conrozier T, Ben Abdallah Y
Infectious Diseases Department, Nord Franche-Comté Hospital, Trevenans, France.
Intensive Care Unit Department, Nord Franche-Comté Hospital, Trevenans, France.
New Microbes New Infect. 2020 Nov;38:100785. doi: 10.1016/j.nmni.2020.100785. Epub 2020 Oct 14.
To our knowledge, Complications such as pneumomediastinum and/or pneumothorax during the course of COVID-19 remain rare and their mechanism is poorly described. We present a case of COVID-19 pneumonia associated with spontaneous pneumothorax, pneumomediastinum and subcutaneous emphysema in an immunocompetent patient with no past history of smoking or chronic obstructive pulmonary disease (COPD). The only risk factor of this patient was prolonged cough. We hypothesize the mechanism underlying the pneumomediastinum is the aggressive disease pathophysiology in COVID-19 with an incresead risk of alveolar damage.
据我们所知,新型冠状病毒肺炎(COVID-19)病程中出现纵隔气肿和/或气胸等并发症仍然罕见,其机制也鲜有描述。我们报告一例COVID-19肺炎合并自发性气胸、纵隔气肿和皮下气肿的病例,该患者免疫功能正常,既往无吸烟史或慢性阻塞性肺疾病(COPD)史。该患者唯一的危险因素是长期咳嗽。我们推测纵隔气肿的潜在机制是COVID-19中具有侵袭性的疾病病理生理学,导致肺泡损伤风险增加。