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肿瘤相关中性粒细胞可预测早期胃癌的淋巴结转移

Tumor-Associated Neutrophils Can Predict Lymph Node Metastasis in Early Gastric Cancer.

作者信息

Wang Yaohui, Zhai Jing, Zhang Tiancheng, Han Shutang, Zhang Yifen, Yao Xuequan, Shen Lizong

机构信息

Department of Pathology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Department of Surgical Oncology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

出版信息

Front Oncol. 2020 Sep 21;10:570113. doi: 10.3389/fonc.2020.570113. eCollection 2020.

DOI:10.3389/fonc.2020.570113
PMID:33072602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7537418/
Abstract

The consensus of endoscopic therapy for early gastric cancer (EGC) mainly depends on its clinicopathological features. However, the roles of tumor-associated neutrophils (TANs) in EGC remain uncertain. Here, we explored its predictive role for lymph node metastasis (LNM) in EGC. Three hundred twenty-two patients who underwent radical gastrectomy for EGC were enrolled. Preoperative peripheral blood was used to analyze the neutrophil-to-lymphocyte ratio (NLR), and the different status of TANs was determined by hematoxylin-and-eosin staining (H&E) and immunohistochemistry (IHC). TANs, rather than NLR, were positively associated with tumor size, Lauren classification, lymphovascular invasion (LVI), and LNM. Univariate analysis revealed that TANs were associated with LNM as well as tumor size, depth of invasion, Lauren classification, histological classification, LVI, and perineural invasion. In addition to histological classification and LVI, TANs were found to be an independent risk factor for LNM in EGC ( = 0.013). Stratification analysis by depth of invasion showed LVI in SM1 tumor, and both LVI and TANs ( = 0.042) in SM2 tumor were independent risk factors for LNM. In conclusion, TANs in EGC can predict LNM, and TANs may help to estimate LNM precisely in addition to the current criteria.

摘要

早期胃癌（EGC）内镜治疗的共识主要取决于其临床病理特征。然而，肿瘤相关中性粒细胞（TANs）在EGC中的作用仍不明确。在此，我们探讨了其对EGC淋巴结转移（LNM）的预测作用。纳入了322例行EGC根治性胃切除术的患者。术前采集外周血分析中性粒细胞与淋巴细胞比值（NLR），通过苏木精-伊红染色（H&E）和免疫组织化学（IHC）确定TANs的不同状态。TANs而非NLR与肿瘤大小、劳伦分类、淋巴管浸润（LVI）和LNM呈正相关。单因素分析显示，TANs与LNM以及肿瘤大小、浸润深度、劳伦分类、组织学分类、LVI和神经周围浸润有关。除组织学分类和LVI外，TANs被发现是EGC中LNM的独立危险因素（=0.013）。按浸润深度进行分层分析显示，SM1期肿瘤中的LVI以及SM2期肿瘤中的LVI和TANs（=0.042）均为LNM的独立危险因素。总之，EGC中的TANs可预测LNM，并且除当前标准外，TANs可能有助于更准确地评估LNM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb93/7537418/04642f41e270/fonc-10-570113-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb93/7537418/308098ae4333/fonc-10-570113-g0007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb93/7537418/308098ae4333/fonc-10-570113-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb93/7537418/688f4ad18c60/fonc-10-570113-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb93/7537418/44771030d6ea/fonc-10-570113-g0002.jpg
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2
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Gastric Cancer. 2021 Jan;24(1):1-21. doi: 10.1007/s10120-020-01042-y. Epub 2020 Feb 14.
3
Hypoxia and Innate Immunity: Keeping Up with the HIFsters.
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Br J Cancer. 2024 Jul;131(2):271-282. doi: 10.1038/s41416-024-02735-2. Epub 2024 Jun 11.
4
Tumor Microenvironment Modulation by Cancer-Derived Extracellular Vesicles.肿瘤细胞衍生的细胞外囊泡对肿瘤微环境的调控作用。
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