Armstrong Rachael E, Frith Lucy, Ulph Fiona M, Southern Kevin W
Department of Women's and Children's Health, University of Liverpool, Liverpool L12 2AP, UK;
Institute of Population Health, University of Liverpool, Liverpool L69 3GL, UK;
Int J Neonatal Screen. 2020 May 26;6(2):40. doi: 10.3390/ijns6020040. eCollection 2020 Jun.
Newborn bloodspot screening for cystic fibrosis is a valid public health strategy for populations with a high incidence of this inherited condition. There are a wide variety of approaches to screening and in this paper, we propose that a bioethical framework is required to determine the most appropriate screening protocol for a population. This framework depends on the detailed evaluation of the ethical consequences of all screening outcomes and placing these in the context of the genetic profile of the population screened, the geography of the region and the healthcare resources available.
对囊性纤维化进行新生儿血斑筛查，对于患有这种遗传性疾病的高发病率人群而言，是一项有效的公共卫生策略。筛查方法多种多样，在本文中，我们提出需要一个生物伦理框架来确定针对某一人群最合适的筛查方案。该框架取决于对所有筛查结果的伦理后果进行详细评估，并将这些后果置于所筛查人群的基因概况、该地区的地理情况以及可用的医疗资源背景之中。
