Liu Yingzhe, Nisisako Takasi
Department of Mechanical Engineering, School of Engineering, Tokyo Institute of Technology, Tokyo 152-8552, Japan.
Institute of Innovative Research, Tokyo Institute of Technology, R2-9, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
ACS Omega. 2020 Oct 5;5(40):25695-25703. doi: 10.1021/acsomega.0c02971. eCollection 2020 Oct 13.
Microencapsulation of biocides is used in long-life antifouling coating paints for marine applications and building materials. Here, we report the microfluidic production of calcium alginate (Ca-alginate) hydrogel particles to modulate the release of the encapsulated drug Irgarol (-cyclopropyl-'-(1,1-dimethylethyl)-6-(methylthio)-1,3,5-triazine-2,4-diamine), which is a hydrophobic and specifically phytotoxic antifoulant that inhibits photosystem II in aquatic plant species. We first encapsulated the drug inside the highly spherical Ca-alginate hydrogels of an average diameter ∼160 μm with a coefficient of variation of less than 4% and an average roundness of more than 0.96. The release speeds of the encapsulated and nonencapsulated drugs in pure water were measured separately by ultraviolet-visible spectroscopy. A stable and controllable release rate of the loaded drug was achieved by hydrophilic encapsulation. In addition, cellulose fibers were incorporated to enhance the mechanical strength of the hydrogels. Finally, the antifouling effect of the encapsulated drug was demonstrated using water grass ().
杀菌剂的微囊化用于海洋应用的长效防污涂料和建筑材料中。在此，我们报道了通过微流控技术制备海藻酸钙（Ca-藻酸盐）水凝胶颗粒，以调节包封药物 Irgarol（-环丙基-'-（1,1-二甲基乙基）-6-（甲硫基）-1,3,5-三嗪-2,4-二胺）的释放，Irgarol 是一种疏水性且具有特定植物毒性的防污剂，可抑制水生植物物种中的光系统 II。我们首先将药物包封在平均直径约为 160μm、变异系数小于 4%且平均圆度大于 0.96 的高度球形 Ca-藻酸盐水凝胶内部。通过紫外可见光谱分别测量了包封药物和未包封药物在纯水中的释放速度。通过亲水性包封实现了负载药物稳定且可控的释放速率。此外，加入纤维素纤维以增强水凝胶的机械强度。最后，用水草展示了包封药物的防污效果。
