Jung Sejin, Song Ryungeun, Kim Jihoon, Ko Jin Hwan, Lee Jinkee
School of Mechanical Engineering , Sungkyunkwan University , Suwon , Gyeonggi-do 16419 , Republic of Korea.
Maritime Robotics Test and Evaluation Unit , Korea Institute of Ocean Science and Technology , Pohang , Gyeongsangbuk-do 37553 , Republic of Korea.
Langmuir. 2020 Feb 18;36(6):1515-1522. doi: 10.1021/acs.langmuir.9b03415. Epub 2020 Feb 4.
As an alternative to the toxic antifouling paint that minimizes the adhesion force between organic molecules on large surfaces, a paint containing hydrogel particles encapsulating amphiphilic liposomes has been suggested. However, the release rate of liposomes, which is important for maximizing the antifouling performance, has not been adequately explored. We investigated the control of the release rate of liposomes encapsulated in alginate. Monodispersed alginate particles were generated using 3D-printed microfluidic devices, and their sizes were varied through the channel size, flow rate, and alginate concentration in the microfluidic devices ([Formula: see text]). The release rate of liposomes from the alginate particles was experimentally monitored under various conditions: alginate concentration, surrounding solution, and ambient fluid flow. The effects of chemical and mechanical stimuli on the effective diffusion coefficient () of amphiphilic liposomes were analyzed, and accordingly, the best production conditions for antifouling alginate particles are suggested. This study provides essential physical insights and is useful for optimizing the performance of eco-friendly antifouling paint that includes alginate particles.
作为一种替代毒性防污漆的方法，有人提出了一种含有包裹两亲性脂质体的水凝胶颗粒的涂料，这种毒性防污漆能使大表面上有机分子之间的附着力最小化。然而，对于最大化防污性能至关重要的脂质体释放速率尚未得到充分研究。我们研究了对包裹在藻酸盐中的脂质体释放速率的控制。使用3D打印微流控装置生成单分散藻酸盐颗粒，并通过微流控装置中的通道尺寸、流速和藻酸盐浓度改变其大小（[公式：见原文]）。在各种条件下通过实验监测脂质体从藻酸盐颗粒中的释放速率：藻酸盐浓度、周围溶液和环境流体流动。分析了化学和机械刺激对两亲性脂质体有效扩散系数（）的影响，并据此提出了防污藻酸盐颗粒的最佳生产条件。本研究提供了重要的物理见解，有助于优化包含藻酸盐颗粒的环保型防污漆的性能。
