School of Chemical Engineering and Technology, Xinjiang University, Urumchi 830046, China.
J Mater Chem B. 2020 Nov 18;8(44):10050-10064. doi: 10.1039/d0tb01869d.
With the advancement of medical research, the source and preparation of biological materials have gradually attracted attention. Hydrogels prepared from natural polysaccharides have been extensively applied in the medical field. The biocompatibility, excellent degradability and low toxicity of chitosan have favored the use of chitosan hydrogels as prospective carriers for drug delivery. Special chitosan hydrogels that effectively release target drugs based on different environmental stimuli have also been developed. This article reviews recent research progress in the development of chemical and physical chitosan hydrogels for drug delivery. In particular, preparation methods together with the chemical and physical properties of chitosan hydrogels are summarized. We also discuss multiple mechanisms of drug release from chitosan hydrogels. Finally, we highlight the future prospects of chitosan hydrogels in medical research.
随着医学研究的进步，生物材料的来源和制备逐渐引起了人们的关注。由天然多糖制备的水凝胶已广泛应用于医学领域。壳聚糖具有良好的生物相容性、优异的可降解性和低毒性，这使得壳聚糖水凝胶成为有前途的药物输送载体。还开发了特殊的壳聚糖水凝胶，可根据不同的环境刺激有效地释放靶向药物。本文综述了近年来用于药物输送的化学和物理壳聚糖水凝胶的研究进展。特别总结了壳聚糖水凝胶的制备方法以及化学和物理性质。我们还讨论了壳聚糖水凝胶药物释放的多种机制。最后，我们强调了壳聚糖水凝胶在医学研究中的未来前景。
