Li Shiyu, Pan Wenlong, Zhang Ming, Song Kailu, Zhou Ziqian, Zhao Qilong, Li Guang-Zhao, Zhu Chongyu
College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.
Key Laboratory of Materials and Surface Technology (Ministry of Education), School of Materials Science and Engineering, Xihua University, Chengdu 610039, China.
Polymers (Basel). 2025 Jun 13;17(12):1647. doi: 10.3390/polym17121647.
The treatment of burn injuries remains a significant global challenge. Although conventional cellulose-based dressings are still the dominant clinical choice, chitosan-based burn wound dressing materials have emerged as a promising alternative due to their unique physicochemical properties and biocompatibility. In this mini-review, we aim to provide a summary of recent advances in chitosan-based dressing materials and highlight their advantages in the treatment of burn wounds. Specifically, we first outline the chemical structure and synthesis methods of chitosan and its derivatives. Subsequently, various forms of chitosan-based dressings are introduced, with a particular focus on hydrogels and micro/nanofibers dressings, along with an overview of their preparation methods. Considering the microenvironment of the burn wound site, we then summarize the design principles and clinical efficacy of chitosan-based dressings with antimicrobial and/or antioxidative activity. Additionally, the applications of chitosan dressings in tissue engineering for burn treatment are also discussed, including growth factor delivery, gene therapy, and stem cell-based treatments. Finally, we examine the main challenges of chitosan-based dressing materials and the potential future directions. Through this mini-review, we expect to provide new perspectives for the development of wound dressings for burn care.
烧伤治疗仍然是一项重大的全球挑战。尽管传统的纤维素基敷料仍是主要的临床选择，但基于壳聚糖的烧伤创面敷料材料因其独特的物理化学性质和生物相容性已成为一种有前景的替代品。在本综述中，我们旨在总结基于壳聚糖的敷料材料的最新进展，并突出它们在烧伤创面治疗中的优势。具体而言，我们首先概述壳聚糖及其衍生物的化学结构和合成方法。随后，介绍了各种形式的基于壳聚糖的敷料，特别关注水凝胶和微/纳米纤维敷料，以及它们的制备方法概述。考虑到烧伤创面部位的微环境，我们接着总结了具有抗菌和/或抗氧化活性的基于壳聚糖的敷料的设计原则和临床疗效。此外，还讨论了壳聚糖敷料在烧伤治疗组织工程中的应用，包括生长因子递送、基因治疗和基于干细胞的治疗。最后，我们审视了基于壳聚糖的敷料材料的主要挑战和潜在的未来方向。通过本综述，我们期望为烧伤护理创面敷料的开发提供新的视角。
