Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
Chemistry. 2021 May 3;27(25):7189-7192. doi: 10.1002/chem.202004151. Epub 2021 Mar 11.
The atroposelective formation of C-N bonds has recently emerged within the field of amination reactions. On first sight, it may seem quite surprising that such an ancient class of organic coupling reactions (Gabriel, Ullmann, Goldberg, Buchwald, Hartwig and many others) has so few enantioselective solutions, and this in spite of asymmetric synthesis being now a mature concept and field. Why should enantioselective C-N bond formation be so difficult? This question and some of the first examples that promise an imminent change of paradigm are herein discussed.
近年来，C-N 键的手性选择性形成在胺化反应领域中崭露头角。乍一看，似乎令人惊讶的是，这样一类古老的有机偶联反应（Gabriel、Ullmann、Goldberg、Buchwald、Hartwig 等）几乎没有对映选择性的解决方案，尽管不对称合成现在已经是一个成熟的概念和领域。为什么对映选择性 C-N 键形成如此困难？本文讨论了这个问题和一些有望立即改变范式的最初例子。
