肥胖与 COVID-19：一块仍缺失部分的拼图。
Obesity and COVID-19: A jigsaw puzzle with still missing pieces.
机构信息
Division of Obesity, Endocrine Practice, Athens, Greece.
1st Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
出版信息
Clin Obes. 2021 Feb;11(1):e12420. doi: 10.1111/cob.12420. Epub 2020 Oct 18.
Abstract
Apart from posing various mechanical and medical issues compromising general health, obesity is a major factor for respiratory tract infections, due to specific inflammation and immunological compromise. The burden of obesity on morbidity and mortality of SARS-CoV-2 infection/COVID-19 is considerable. Herein, we aimed to search the literature and present to the readers pathophysiologic pathways that may associate obesity and COVID-19. We present potential mechanisms, which might partly explain why patients with obesity are more prone to suffer from respiratory infections in the context of COVID-19. Better understanding of these pathways could eventually guide management strategies and therapies for COVID-19 in the future.
摘要
除了引发各种影响整体健康的机械和医学问题外，肥胖也是导致呼吸道感染的一个主要因素，这是由于其特殊的炎症和免疫功能受损。肥胖对 SARS-CoV-2 感染/COVID-19 发病率和死亡率的影响是相当大的。在此，我们旨在搜索文献并向读者展示可能与肥胖和 COVID-19 相关的病理生理途径。我们提出了一些潜在的机制，这些机制可能部分解释了为什么肥胖患者在 COVID-19 背景下更容易患呼吸道感染。更好地了解这些途径可能最终会为未来 COVID-19 的管理策略和治疗提供指导。
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