Metabolic Disorders and Inflammatory Pathologies Laboratory, School of Life Sciences, Central University of Gujarat, Sector 30, Gandhinagar, Gujarat, 382030, India.
Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Obes Res Clin Pract. 2021 Mar-Apr;15(2):163-171. doi: 10.1016/j.orcp.2021.01.004. Epub 2021 Jan 19.
With the global spread of SARS-CoV-2, millions of people have been affected leading to the declaration of coronavirus disease 2019 (COVID-19) as a pandemic by the WHO. Several studies have linked the severity of COVID-19 cases and increased fatality in patients with obesity and other comorbid conditions such as diabetes, cardiovascular diseases, hypertension, and kidney disease. Obesity, a metabolically deranged condition, establishes a low-grade chronic inflammation in the body, which affects different organs and promotes the development of several other diseases. The ways in which SARS-CoV-2 infection aggravates the already overloaded body organs with inflammation or vice versa has perplexed the researchers. As a result, there is an intensified search for the clear-cut mechanism to understand the link of obesity with the increased severity of COVID-19 in obese patients. In this article we have discussed various mechanisms linking obesity, inflammation, and COVID-19 to enhance the understanding of the disease process and help the clinicians and scientists develop potential cellular, molecular and metabolic targets for clinical intervention and management of COVID-19 severity in obese patients.
随着 SARS-CoV-2 在全球范围内的传播，数以百万计的人受到了影响，世界卫生组织宣布 2019 年冠状病毒病（COVID-19）为大流行。多项研究表明，肥胖症患者和其他合并症（如糖尿病、心血管疾病、高血压和肾脏疾病）患者的 COVID-19 病例严重程度和死亡率增加与肥胖症有关。肥胖症是一种代谢失调的疾病，会导致体内低度慢性炎症，影响不同的器官，并促进其他几种疾病的发展。SARS-CoV-2 感染是如何加重已经负担过重的器官炎症，或者反之亦然，这让研究人员感到困惑。因此，人们正在加紧寻找明确的机制，以了解肥胖症与肥胖症患者 COVID-19 严重程度增加之间的联系。在本文中，我们讨论了将肥胖症、炎症和 COVID-19 联系起来的各种机制，以增强对疾病过程的理解，并帮助临床医生和科学家为肥胖患者 COVID-19 严重程度的临床干预和管理开发潜在的细胞、分子和代谢靶点。
