School of Basic Medical Sciences, Shandong Second Medical University, Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, Weifang, Shandong, China.
School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong, China.
PeerJ. 2024 Oct 30;12:e18313. doi: 10.7717/peerj.18313. eCollection 2024.
The ongoing high occurrence of harmful infectious diseases significantly threatens human health. Existing methods used to control such diseases primarily involve targeting the pathogens, usually neglecting the vital role of host factors in disease advancement. Gamma delta (γδ) T cells act as a bridge between innate and adaptive immunity, playing a crucial role in combating pathogen invasion. Among these γδT cell subsets, which are categorized based on T cell receptor delta variable expression patterns, V delta (δ) 1 T cells possess unique recognition abilities and regulatory characteristics and actively engage in various immune responses. The differentiation, development, and immune reactivity of Vδ1 T cells are closely associated with the initial and progressive stages of infectious diseases. This article provides an overview of the classification, distribution, differentiation, and development of Vδ1 T cells and their mechanisms in combating pathogenic infections, offering new insights for disease diagnosis and treatment.
不断高发的有害传染病严重威胁着人类健康。目前用于控制此类疾病的方法主要针对病原体，通常忽略了宿主因素在疾病进展中的重要作用。γδ（γδ）T 细胞作为先天免疫和适应性免疫之间的桥梁，在抵御病原体入侵方面发挥着关键作用。在这些根据 T 细胞受体 δ 可变表达模式分类的 γδT 细胞亚群中，Vδ（δ）1 T 细胞具有独特的识别能力和调节特性，并积极参与各种免疫反应。Vδ1 T 细胞的分化、发育和免疫反应性与传染病的初始和进展阶段密切相关。本文综述了 Vδ1 T 细胞的分类、分布、分化和发育及其在抗病原感染中的机制，为疾病的诊断和治疗提供了新的思路。
