Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio" , Chieti, Italy.
Electromagn Biol Med. 2021 Jan 2;40(1):11-25. doi: 10.1080/15368378.2020.1830290. Epub 2020 Oct 17.
Among haematological parameters of patients seriously ill with the coronavirus infectious disease 2019 (COVID-19), leucocytosis, lymphocytopenia, and the abnormal release of circulating cytokines, termed cytokine storm syndrome (CSS, also known as cytokine release syndrome or CRS), were found associated with disease severity. In particular, according to the serum cytokine profiling, pro-inflammatory interleukin 6 (IL-6) and anti-inflammatory interleukin 10 (IL-10) were observed to be considerably higher in patients experiencing respiratory distress, septic shock and/or multi-organ failure, namely "critical cases" requiring intensive care unit (ICU) admission, very often resulting in death. Interestingly, the production of these cytokines from human lymphocytes was found to be modulated by exposure of 24 h to a 554.2-553.8 mT inhomogeneous static magnetic field (SMF), which elicits IL-10 and suppresses IL-6. Thus, herein, with the aim of restoring lymphocyte count and physiological serum levels of IL-6 and IL-10, the infusion of human leukocyte antigen (HLA)-matched and SMF-exposed allogenic lymphocytes is proposed for the first time as an easy and affordable treatment option for COVID-19 patients. Even if the count of lymphocytes in COVID-19 patients is very low, SMF exposure may be a valuable tool for reprogramming autologous lymphocytes towards physiological conditions. Furthermore, the same procedure could be extended to include the whole autologous or allogenic white blood cells (WBCs). Time-varying/pulsed magnetic fields exerting comparable cell effects could also be employed.
在患有 2019 年冠状病毒病(COVID-19)的严重患者的血液学参数中,发现白细胞增多、淋巴细胞减少以及循环细胞因子的异常释放,称为细胞因子风暴综合征(CSS,也称为细胞因子释放综合征或 CRS),与疾病严重程度相关。特别是,根据血清细胞因子分析,在出现呼吸窘迫、感染性休克和/或多器官衰竭的患者中(即需要入住重症监护病房(ICU)的“重症病例”),观察到促炎白细胞介素 6(IL-6)和抗炎白细胞介素 10(IL-10)显著升高,这非常常见导致死亡。有趣的是,发现人体淋巴细胞产生这些细胞因子的方式可通过暴露于 554.2-553.8 mT 不均匀静磁场(SMF)24 小时来调节,从而引发 IL-10 并抑制 IL-6。因此,本文旨在恢复淋巴细胞计数和 COVID-19 患者生理血清中 IL-6 和 IL-10 的水平,首次提出输注人类白细胞抗原(HLA)匹配并经 SMF 暴露的同种异体淋巴细胞作为 COVID-19 患者的一种简单且负担得起的治疗选择。即使 COVID-19 患者的淋巴细胞计数非常低,SMF 暴露也可能是一种对自身淋巴细胞进行重编程以恢复生理状态的有价值的工具。此外,同一程序可扩展到包括整个自身或同种异体白细胞(WBCs)。还可以采用产生类似细胞效应的时变/脉冲磁场。
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