文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

输注 HLA 匹配且经静磁场暴露的同种异体淋巴细胞治疗淋巴细胞减少症和细胞因子风暴综合征:COVID-19 患者的治疗建议。

Infusion of HLA-matched and static magnetic field-exposed allogenic lymphocytes treating lymphocytopenia and cytokine storm syndrome: A treatment proposal for COVID-19 patients.

机构信息

Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio" , Chieti, Italy.

出版信息

Electromagn Biol Med. 2021 Jan 2;40(1):11-25. doi: 10.1080/15368378.2020.1830290. Epub 2020 Oct 17.


DOI:10.1080/15368378.2020.1830290
PMID:33073612
Abstract

Among haematological parameters of patients seriously ill with the coronavirus infectious disease 2019 (COVID-19), leucocytosis, lymphocytopenia, and the abnormal release of circulating cytokines, termed cytokine storm syndrome (CSS, also known as cytokine release syndrome or CRS), were found associated with disease severity. In particular, according to the serum cytokine profiling, pro-inflammatory interleukin 6 (IL-6) and anti-inflammatory interleukin 10 (IL-10) were observed to be considerably higher in patients experiencing respiratory distress, septic shock and/or multi-organ failure, namely "critical cases" requiring intensive care unit (ICU) admission, very often resulting in death. Interestingly, the production of these cytokines from human lymphocytes was found to be modulated by exposure of 24 h to a 554.2-553.8 mT inhomogeneous static magnetic field (SMF), which elicits IL-10 and suppresses IL-6. Thus, herein, with the aim of restoring lymphocyte count and physiological serum levels of IL-6 and IL-10, the infusion of human leukocyte antigen (HLA)-matched and SMF-exposed allogenic lymphocytes is proposed for the first time as an easy and affordable treatment option for COVID-19 patients. Even if the count of lymphocytes in COVID-19 patients is very low, SMF exposure may be a valuable tool for reprogramming autologous lymphocytes towards physiological conditions. Furthermore, the same procedure could be extended to include the whole autologous or allogenic white blood cells (WBCs). Time-varying/pulsed magnetic fields exerting comparable cell effects could also be employed.

摘要

在患有 2019 年冠状病毒病(COVID-19)的严重患者的血液学参数中,发现白细胞增多、淋巴细胞减少以及循环细胞因子的异常释放,称为细胞因子风暴综合征(CSS,也称为细胞因子释放综合征或 CRS),与疾病严重程度相关。特别是,根据血清细胞因子分析,在出现呼吸窘迫、感染性休克和/或多器官衰竭的患者中(即需要入住重症监护病房(ICU)的“重症病例”),观察到促炎白细胞介素 6(IL-6)和抗炎白细胞介素 10(IL-10)显著升高,这非常常见导致死亡。有趣的是,发现人体淋巴细胞产生这些细胞因子的方式可通过暴露于 554.2-553.8 mT 不均匀静磁场(SMF)24 小时来调节,从而引发 IL-10 并抑制 IL-6。因此,本文旨在恢复淋巴细胞计数和 COVID-19 患者生理血清中 IL-6 和 IL-10 的水平,首次提出输注人类白细胞抗原(HLA)匹配并经 SMF 暴露的同种异体淋巴细胞作为 COVID-19 患者的一种简单且负担得起的治疗选择。即使 COVID-19 患者的淋巴细胞计数非常低,SMF 暴露也可能是一种对自身淋巴细胞进行重编程以恢复生理状态的有价值的工具。此外,同一程序可扩展到包括整个自身或同种异体白细胞(WBCs)。还可以采用产生类似细胞效应的时变/脉冲磁场。

相似文献

[1]
Infusion of HLA-matched and static magnetic field-exposed allogenic lymphocytes treating lymphocytopenia and cytokine storm syndrome: A treatment proposal for COVID-19 patients.

Electromagn Biol Med. 2021-1-2

[2]
Selection of the Appropriate Control Group Is Essential in Evaluating the Cytokine Storm in COVID-19.

In Vivo. 2021

[3]
Targeting Cytokine Storm to Manage Patients with COVID-19: A Mini-Review.

Arch Med Res. 2020-6-19

[4]
Coronavirus-19 (SARS-CoV-2) induces acute severe lung inflammation via IL-1 causing cytokine storm in COVID-19: a promising inhibitory strategy.

J Biol Regul Homeost Agents. 2020

[5]
Sepsis-associated severe interleukin-6 storm in critical coronavirus disease 2019.

Cell Mol Immunol. 2020-10

[6]
The journey of SARS-CoV-2 in human hosts: a review of immune responses, immunosuppression, and their consequences.

Virulence. 2021-12

[7]
The Effect of Static Magnetic Fields of Different Strengths and Polarities on Cytokine Production by Human Lymphocytes In Vitro.

Bioengineering (Basel). 2024-7-24

[8]
Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis.

JCI Insight. 2020-9-3

[9]
Are all cytokine storms the same?

Cancer Immunol Immunother. 2021-4

[10]
In vitro analysis of the anti-inflammatory effect of inhomogeneous static magnetic field-exposure on human macrophages and lymphocytes.

PLoS One. 2013-8-26

引用本文的文献

[1]
Safety of Exposure to 0.2 T and 4 Hz Rotating Magnetic Field: A Ten-Month Study on C57BL/6 Mice.

Curr Issues Mol Biol. 2024-6-26

[2]
Intermittent ELF-MF Induce an Amplitude-Window Effect on Umbilical Cord Blood Lymphocytes.

Int J Mol Sci. 2022-11-19

[3]
Vagus Nerve Stimulation: A Potential Adjunct Therapy for COVID-19.

Front Med (Lausanne). 2021-5-7

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索