University of São Paulo, São Paulo, Brazil.
Department of Internal Medicine, Faculdade De Medicina Da Universidade De São Paulo, São Paulo, Brazil.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2021 Nov;28(6):871-883. doi: 10.1080/13825585.2020.1837723. Epub 2020 Oct 19.
Glaucoma, cataracts, and cognitive decline are most common in older ages. Although cross-sectional studies showed that these disorders are associated, follow-up studies are lacking. To investigate this issue, baseline and follow-up data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) were employed. We evaluated participants ≥ 55 years-old at follow-up without diagnosis of dementia, stroke, and other eye conditions except for glaucoma and cataracts. Cognition was evaluated using delayed word recall, verbal fluency, and trail making (version B) tests. Regression models were employed to investigate associations between glaucoma and cognition, adjusted by several confounders. Out of 3,867 participants, 379 and 118 presented cataracts and glaucoma, respectively. Only glaucoma was apredictor of lower verbal fluency (B = -0.23, 95% CI -035 to -012, p< 0.001). Other associations were not significant (ps>0.57). Our results suggest that glaucoma may be related to declining cognition.
青光眼、白内障和认知能力下降在老年人中最为常见。虽然横断面研究表明这些疾病是相关的，但缺乏随访研究。为了研究这个问题，我们使用了巴西成年人健康纵向研究（ELSA-Brasil）的基线和随访数据。我们评估了在随访时年龄≥55 岁、没有痴呆、中风和其他眼部疾病（除青光眼和白内障外）诊断的参与者。认知能力通过延迟单词回忆、语言流畅性和追踪测试（B 版）进行评估。回归模型用于研究青光眼和认知之间的关联，并通过多种混杂因素进行调整。在 3867 名参与者中，分别有 379 人和 118 人患有白内障和青光眼。只有青光眼是语言流畅性降低的预测因素（B=-0.23，95%CI-0.35 至-0.12，p<0.001）。其他关联没有统计学意义（p>0.57）。我们的结果表明，青光眼可能与认知能力下降有关。
