Zhang Yanyan, Qin Pei, Lou Yanmei, Zhao Ping, Li Xue, Qie Ranran, Wu Xiaoyan, Han Minghui, Huang Shengbing, Zhao Yang, Liu Dechen, Wu Yuying, Li Yang, Yang Xingjin, Zhao Yang, Feng Yifei, Wang Changyi, Ma Jianping, Peng Xiaolin, Chen Hongen, Zhao Dan, Xu Shan, Wang Li, Luo Xinping, Zhang Ming, Hu Dongsheng, Hu Fulan
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China.
Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, People's Republic of China.
J Diabetes. 2020 Oct 19. doi: 10.1111/1753-0407.13123.
The association of ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C ratio) change trajectory with risk of type 2 diabetes mellitus (T2DM) remains unknown. The aim of this study was to evaluate the association between risk of T2DM and TG/HDL-C ratio change trajectory.
A total of 18 444 participants aged 18-80 years old were included in this cohort study. Linear regression and quadratic regression models were used to determine the TG/HDL-C ratio change trajectory. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between TG/HDL-C ratio change trajectory and probability of T2DM.
T2DM developed in 714 participants during a median follow-up of 5.74 years (92 076.23 person-years of follow-up). After adjusting for baseline potential confounders, odds of T2DM were greater for participants with the increasing, U-shape, bell-shape, and other shape change vs decreasing change (adjusted OR [aOR] 2.01, 95% CI 1.42-2.81; 1.56, 1.15-2.13; 1.60, 1.17-2.20; and 1.49, 1.13-2.00, respectively). The results were robust in the sensitivity analyses on excluding baseline participants with T2DM. Moreover, the associations remained significant with male sex, age <60 years and body mass index <24 kg/m .
This retrospective study revealed increased probability of T2DM with increasing, U-shape, bell-shape, and other-shape TG/HDL-C ratio change trajectories, especially with male sex, age <60 years and body mass index <24 kg/m .
甘油三酯与高密度脂蛋白胆固醇比值（TG/HDL-C比值）变化轨迹与2型糖尿病（T2DM）风险之间的关联尚不清楚。本研究旨在评估T2DM风险与TG/HDL-C比值变化轨迹之间的关联。
本队列研究共纳入18444名年龄在18至80岁之间的参与者。使用线性回归和二次回归模型确定TG/HDL-C比值变化轨迹。采用逻辑回归估计TG/HDL-C比值变化轨迹与T2DM发生概率之间关联的比值比（OR）和95%置信区间（CI）。
在中位随访5.74年（92076.23人年随访）期间，714名参与者发生了T2DM。在调整基线潜在混杂因素后，与TG/HDL-C比值下降变化相比，TG/HDL-C比值呈上升、U形、钟形和其他形状变化的参与者患T2DM的几率更高（调整后的OR[aOR]分别为2.01，95%CI为1.42-2.81；1.56，1.15-2.13；1.60，1.17-2.20；1.49，1.13-2.00）。在排除基线患有T2DM的参与者的敏感性分析中，结果是稳健的。此外，在男性、年龄<60岁和体重指数<24kg/m²的人群中，这种关联仍然显著。
这项回顾性研究表明，随着TG/HDL-C比值呈上升、U形、钟形和其他形状变化轨迹，T2DM发生的概率增加，尤其是在男性、年龄<60岁和体重指数<24kg/m²的人群中。
