Mirr Małgorzata, Braszak-Cymerman Anna, Ludziejewska Aleksandra, Kręgielska-Narożna Matylda, Bogdański Paweł, Bryl Wiesław, Owecki Maciej
Department of Public Health, Poznan University of Medical Sciences, Rokietnicka St. 4, 60-806 Poznań, Poland.
The Doctoral School of the Poznan University of Medical Sciences, Bukowska St. 70, 60-812 Poznań, Poland.
Biomedicines. 2023 May 28;11(6):1568. doi: 10.3390/biomedicines11061568.
Insulin resistance is a major contributor to the development of type 2 diabetes and can be assessed using indirect indicators calculated from non-invasive tests. Asprosin is a recently discovered adipokine with a postulated effect on glycemic regulation. This study aimed to investigate the correlation between serum asprosin levels and insulin resistance indices. The correlation between circulating asprosin and obesity indices was also investigated.
A total of 50 non-diabetic patients with obesity and 50 healthy volunteers were studied. Laboratory data, including circulating asprosin and anthropometric data, were collected. The following insulin resistance indices were calculated: triglyceride-glucose index (TyG), TyG-neck circumference (TyG-NC), TyG-neck circumference to height ratio (TyG-NHtR), TyG-waist circumference (TyG-WC), TyG-waist to height ratio (TyG-WHtR), TyG-body mass index (TyG-BMI), and the ratio between triglycerides and high-density cholesterol (TG/HDLc). The obtained data were analyzed separately for males and females.
Asprosin concentrations were significantly higher in obese patients ( < 0.001). Asprosin concentrations positively correlated with body mass index ( < 0.001, r = 0.8 in females and r = 0.8 in males), waist circumference ( < 0.001, r = 0.73 in females and r = 0.81 in males), and all tested indices of insulin resistance. The strongest correlation was observed for TyG-BMI ( < 0.001, r = 0.78 in females and r = 0.81 in males). Circulating asprosin was higher in females ( < 0.001).
Asprosin can be considered a marker of obesity and insulin resistance.
胰岛素抵抗是2型糖尿病发生发展的主要因素，可通过无创检测计算出的间接指标进行评估。Asprosin是一种最近发现的脂肪因子，推测其对血糖调节有影响。本研究旨在探讨血清Asprosin水平与胰岛素抵抗指数之间的相关性。还研究了循环Asprosin与肥胖指数之间的相关性。
共研究了50名肥胖的非糖尿病患者和50名健康志愿者。收集了包括循环Asprosin在内的实验室数据和人体测量数据。计算了以下胰岛素抵抗指数：甘油三酯-葡萄糖指数（TyG）、TyG-颈围（TyG-NC）、TyG-颈围与身高比（TyG-NHtR）、TyG-腰围（TyG-WC）、TyG-腰高比（TyG-WHtR）、TyG-体重指数（TyG-BMI）以及甘油三酯与高密度胆固醇之比（TG/HDLc）。所获数据分别对男性和女性进行分析。
肥胖患者的Asprosin浓度显著更高（<0.001）。Asprosin浓度与体重指数呈正相关（<0.001，女性r = 0.8，男性r = 0.8）、腰围（<0.001，女性r = 0.73，男性r = 0.81）以及所有检测的胰岛素抵抗指数。TyG-BMI的相关性最强（<0.001，女性r = 0.78，男性r = 0.81）。女性的循环Asprosin更高（<0.001）。
Asprosin可被视为肥胖和胰岛素抵抗的标志物。
