Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Bristol Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States.
Org Lett. 2020 Nov 6;22(21):8714-8719. doi: 10.1021/acs.orglett.0c03308. Epub 2020 Oct 19.
A short, scalable total synthesis of meayamycin is described by an approach that entails a longest linear sequence of 12 steps (22 steps overall) from commercially available chiral pool materials (ethyl l-lactate, BocNH-Thr-OH, and d-ribose) and introduces the most straightforward preparation of the right-hand subunit detailed to date. The use of the approach in the divergent synthesis of a representative series of -acyl analogues is exemplified.
本文描述了一种短、可扩展的美阿霉素全合成方法，该方法采用了从商业可得的手性池原料（L-乳酸乙酯、BocNH-Thr-OH 和 D-核糖）出发的最长线性序列 12 步（总步骤为 22 步），并引入了迄今为止最直接的右手亚基制备方法。该方法在一系列代表性的 -酰基类似物的发散合成中的应用得到了例证。
