Sequential conditional reinforcement learning for simultaneous vertebral body detection and segmentation with modeling the spine anatomy.

Accurate vertebral body (VB) detection and segmentation are critical for spine disease identification and diagnosis. Existing automatic VB detection and segmentation methods may cause false-positive results to the background tissue or inaccurate results to the desirable VB. Because they usually cannot take both the global spine pattern and the local VB appearance into consideration concurrently. In this paper, we propose a Sequential Conditional Reinforcement Learning network (SCRL) to tackle the simultaneous detection and segmentation of VBs from MR spine images. The SCRL, for the first time, applies deep reinforcement learning into VB detection and segmentation. It innovatively models the spatial correlation between VBs from top to bottom as sequential dynamic-interaction processes, thereby globally focusing detection and segmentation on each VB. Simultaneously, SCRL also perceives the local appearance feature of each desirable VB comprehensively, thereby achieving accurate detection and segmentation result. Particularly, SCRL seamlessly combines three parts: 1) Anatomy-Modeling Reinforcement Learning Network dynamically interacts with the image and focuses an attention-region on the VB; 2) Fully-Connected Residual Neural Network learns rich global context information of the VB including both the detailed low-level features and the abstracted high-level features to detect the accurate bounding-box of the VB based on the attention-region; 3) Y-shaped Network learns comprehensive detailed texture information of VB including multi-scale, coarse-to-fine features to segment the boundary of VB from the attention-region. On 240 subjects, SCRL achieves accurate detection and segmentation results, where on average the detection IoU is 92.3%, segmentation Dice is 92.6%, and classification mean accuracy is 96.4%. These excellent results demonstrate that SCRL can be an efficient aided-diagnostic tool to assist clinicians when diagnosing spinal diseases.