Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India,
Dement Geriatr Cogn Disord. 2020;49(5):471-482. doi: 10.1159/000510219. Epub 2020 Oct 19.
Cystatin C (Cys C) has been found as a novel biomarker of neurodegenerative diseases, such as dementia and Alzheimer's disease. Published studies on the role of Cys C as a biomarker of mild cognitive impairment (MCI) have not been reviewed systematically.
Present meta-analysis was performed to elucidate the association between Cys C and risk of MCI.
A comprehensive search was performed in PubMed, EMBASE, Cochrane Library, Trip databases, Worldwide Science, and Google Scholar from January 1, 1950, to April 30, 2020. Standardized mean difference (SMD) with 95% confidence interval (CI) using fixed or random effect models were used to calculate summary estimates. Quality of evidence was also assessed using the Diagnostic Accuracy Quality Scale (DAQS) and grading quality of evidence and strength of recommendations approach.
In our meta-analysis, 12 studies with a total of 2,433 MCI patients and 1,034 controls were included. Our findings suggest a strong association between increased levels of Cys C and risk of MCI as compared to control subjects (SMD = 2.39, 95% CI = 0.22-4.57). Subgroup analysis based on ethnicity, a significant association for the high level of Cys C with the risk of MCI was observed in the Asian population (SMD = 1.63, 95% CI = 0.44-2.82) but not in the Caucasian population (SMD = 2.80, 95% CI = [-0.66]-6.26).
Cys C was associated with MCI, and it could be considered as a predictor for the risk of cognitive impairment.
半胱氨酸蛋白酶抑制剂 C（Cys C）已被发现为神经退行性疾病（如痴呆和阿尔茨海默病）的新型生物标志物。已发表的关于 Cys C 作为轻度认知障碍（MCI）生物标志物的作用的研究尚未进行系统审查。
本荟萃分析旨在阐明 Cys C 与 MCI 风险之间的关系。
从 1950 年 1 月 1 日至 2020 年 4 月 30 日，在 PubMed、EMBASE、Cochrane 图书馆、Trip 数据库、Worldwide Science 和 Google Scholar 中进行了全面检索。使用固定或随机效应模型计算标准均数差值（SMD）及其 95%置信区间（CI），以计算汇总估计值。还使用诊断准确性质量量表（DAQS）和证据质量分级和推荐强度方法评估证据质量。
在我们的荟萃分析中，共纳入了 12 项研究，总计 2433 例 MCI 患者和 1034 例对照。我们的研究结果表明，与对照相比，Cys C 水平升高与 MCI 风险之间存在很强的关联（SMD=2.39，95%CI=0.22-4.57）。基于种族的亚组分析显示，在亚洲人群中，高水平的 Cys C 与 MCI 风险之间存在显著关联（SMD=1.63，95%CI=0.44-2.82），而在白人群体中则无此关联（SMD=2.80，95%CI=-0.66-6.26）。
Cys C 与 MCI 相关，可作为认知障碍风险的预测指标。
