Wang Shuli, Lin Xuechun, Zhou Jie, Li Meng, Song Dan
Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Neurosci. 2023 May 3;17:1200763. doi: 10.3389/fnins.2023.1200763. eCollection 2023.
Serum Cystatin C level, an indication of kidney function, has been implicated in the pathogenesis of Alzheimer's disease and cognitive impairment. In this cross-sectional study, we looked into the relation between serum Cystatin C levels and cognition in a group of U.S. older adults.
The data of this study were from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. A total of 4,832 older adults aged ≥60 who met the inclusion criteria were included. The Dade Behring N Latex Cystatin C assay, which is a particle-enhanced nephelometric assay (PENIA), was utilized to assess Cystatin C levels in participants' blood samples. Participants' cognition was examined using the digit symbol substitution test (DSST). -scores of the DSST were calculated based on sample means and standard deviations (SD). To investigate the relationships between the quartiles of serum Cystatin C level and DSST scores, multiple linear regression models were developed while controlling for age, sex, race/ethnicity, and education.
The average age of the participants was 71.1 (SD 7.8). The participants were about half female (50.5%), non-Hispanic White (61.2%), and (36.1%) who had completed at least some college. They had an average serum Cystatin C level of 1.0 mg/dl (SD 0.44). After performing multiple linear regression with a reference group consisting of participants in quartile one of plasma Cystatin C levels, we found that serum Cystatin C levels in quartiles three and four were independently associated with lower DSST scores (β = -0.059, 95% CI -0.200 to -0.074 and β = -0.108, 95% CI -0.319 to -0.184, respectively).
Higher serum Cystatin C level is associated with worse processing speed, sustained attention, and working memory in older adults. Cystatin C level may be a biomarker for cognitive decline in older adults.
血清胱抑素C水平是肾功能的一个指标，已被认为与阿尔茨海默病和认知障碍的发病机制有关。在这项横断面研究中，我们调查了一组美国老年人血清胱抑素C水平与认知之间的关系。
本研究的数据来自1999 - 2002年的美国国家健康与营养检查调查（NHANES）。共有4832名年龄≥60岁且符合纳入标准的老年人被纳入研究。采用Dade Behring N Latex胱抑素C检测法，即一种颗粒增强散射比浊法（PENIA），来评估参与者血样中的胱抑素C水平。使用数字符号替换测验（DSST）对参与者的认知进行检查。DSST得分是根据样本均值和标准差（SD）计算得出的。为了研究血清胱抑素C水平四分位数与DSST得分之间的关系，在控制年龄、性别、种族/民族和教育程度的同时建立了多元线性回归模型。
参与者的平均年龄为71.1岁（SD 7.8）。参与者中约一半为女性（50.5%），非西班牙裔白人（61.2%），并且（36.1%）至少完成了一些大学学业。他们的血清胱抑素C平均水平为1.0mg/dl（SD 0.44）。在以血浆胱抑素C水平四分位数中的第一组参与者为参照组进行多元线性回归后，我们发现四分位数三及四分位数四的血清胱抑素C水平与较低的DSST得分独立相关（β = -0.059，95%CI -0.200至 -0.074；β = -0.108，95%CI -0.319至 -0.184）。
较高的血清胱抑素C水平与老年人较差的处理速度、持续注意力和工作记忆相关。胱抑素C水平可能是老年人认知衰退的一个生物标志物。
