The Nutrition and Brain Health Laboratory, The Institute of Biochemistry, Food and Nutrition Science, The Robert H. Smith Faculty of Agriculture Food and the Environment, The Hebrew University of Jerusalem, 7610001 Rehovot, Israel.
The Joseph Sagol Neuroscience Center, Sheba Medical Center, 5265601 Tel Hashomer, Israel.
Nutrients. 2020 Oct 15;12(10):3143. doi: 10.3390/nu12103143.
High serum concentrations of advanced glycation end-products (AGEs) in older adults and diabetics are associated with an increased risk of cognitive impairment. The aim of this pilot study was to assess the feasibility of long-term adherence to a dietary intervention designed to decrease intake and exposure to circulating AGEs among older adults with type 2 diabetes.
Herein, 75 participants were randomized to either a standard of care (SOC) control arm or to an intervention arm receiving instruction on reducing dietary AGEs intake. The primary outcome was a change in serum AGEs at the end of the intervention. Secondary and exploratory outcomes included adherence to diet and its association with circulating AGEs. Cognitive function and brain imaging were also assessed but were out of the scope of this article (ClinicalTrials.gov Identifier: NCT02739971).
The intervention resulted in a significant change over time in several serum AGEs compared to the SOC guidelines. Very high adherence (above 80%) to the AGE-lowering diet was associated with a greater reduction in serum AGEs levels. There were no significant differences between the two arms in any other metabolic markers.
A long-term dietary intervention to reduce circulating AGEs is feasible in older adults with type 2 diabetes, especially in those who are highly adherent to the AGE-lowering diet.
老年人和糖尿病患者血清中晚期糖基化终产物（AGEs）浓度升高与认知障碍风险增加有关。本研究旨在评估通过饮食干预降低 2 型糖尿病老年患者体内循环 AGEs 摄入量和暴露量的长期依从性的可行性。
75 名参与者被随机分配到标准护理（SOC）对照组或接受减少饮食 AGEs 摄入量指导的干预组。主要结局是干预结束时血清 AGEs 的变化。次要和探索性结局包括饮食的依从性及其与循环 AGEs 的关系。认知功能和脑成像也进行了评估，但不在本文范围内（临床试验标识符：NCT02739971）。
与 SOC 指南相比，干预后几种血清 AGEs 随时间发生显著变化。非常高的（高于 80%）对降低 AGE 饮食的依从性与血清 AGEs 水平的更大降低相关。两组之间在任何其他代谢标志物方面均无显著差异。
降低循环 AGEs 的长期饮食干预在 2 型糖尿病老年患者中是可行的，尤其是在高度依从降低 AGE 饮食的患者中。
