Panic Nikola, Mihajlovic Sladjana, Vujasinovic Miroslav, Bulajic Milutin, Löhr Johannes-Matthias
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Digestive Endoscopy Unit, University Clinic "Dr Dragisa Misovic-Dedinje", 11000 Belgrade, Serbia.
J Clin Med. 2020 Oct 15;9(10):3309. doi: 10.3390/jcm9103309.
We conducted a systematic review in order to summarize the available data on pancreatitis associated with viral hepatitis.
A comprehensive literature search of Medline, Scopus and ISI Web of Science databases was conducted and papers eligible for the inclusion identified.
In total, 46 studies reporting data on 73 patients were included in the analysis. Most of the cases were diagnosed in Asia (57.53%), followed by North America (23.29%), and Europe (13.70%). Most of the patients were affected by hepatitis A virus (HAV) (42.47%), followed by hepatitis E virus (HEV) (28.77%), hepatitis B virus (HBV) (8.22%), and hepatitis C virus (HCV) (1.37%), while 17.81% at the time of diagnosis were classified as affected by "hepatitis virus". Pancreatitis was severe in 32.88% of cases. The respiratory system was affected in 2.74% of patients, 6.85% experienced renal failure, while 5.48% experienced a multiorgan dysfunction syndrome (MODS). Four patients (5.48%) needed pancreatic surgery. Despite the treatment, 21.92% of patients died. We identified fulminant hepatitis ( < 0.0001), MODS ( < 0.0001) and severe pancreatitis ( < 0.0001) to be significantly more present in patients who died in comparison to cured ones.
Increased awareness of pancreatic involvement in viral hepatitis is needed because it can have a substantial impact on therapeutic approaches and outcomes.
我们进行了一项系统评价，以总结与病毒性肝炎相关的胰腺炎的现有数据。
对Medline、Scopus和ISI Web of Science数据库进行了全面的文献检索，并确定了符合纳入标准的论文。
总共46项报告73例患者数据的研究纳入了分析。大多数病例在亚洲被诊断（57.53%），其次是北美（23.29%）和欧洲（13.70%）。大多数患者感染甲型肝炎病毒（HAV）（42.47%），其次是戊型肝炎病毒（HEV）（28.77%）、乙型肝炎病毒（HBV）（8.22%）和丙型肝炎病毒（HCV）（1.37%），而在诊断时17.81%被归类为受“肝炎病毒”感染。32.88%的病例胰腺炎严重。2.74%的患者呼吸系统受累，6.85%出现肾衰竭，而5.48%出现多器官功能障碍综合征（MODS）。4例患者（5.48%）需要进行胰腺手术。尽管进行了治疗，仍有21.92%的患者死亡。我们发现，与治愈的患者相比，暴发性肝炎（<0.0001）、MODS（<0.0001）和严重胰腺炎（<0.0001）在死亡患者中明显更为常见。
需要提高对病毒性肝炎中胰腺受累的认识，因为它可能对治疗方法和结果产生重大影响。
