Kumar V, Hemedinger E, Chorzelski T P, Beutner E H, Valeski J E, Kowalewski C
Arch Dermatol. 1987 Sep;123(9):1179-82.
Reticulin antibodies of IgG- and IgA-class and endomysial antibodies, which are of the IgA class, were studied by indirect immunofluorescence in 30 normal subjects, and in 45 patients with dermatitis herpetiformis (DH), 31 with pemphigoid, and 30 with pemphigus. Endomysial antibodies were present in 65% of patients with DH maintained on a normal diet and were absent in those on a gluten-free diet and in those with other diseases and in normal controls. Reticulin antibodies of the IgA class were disease specific for DH and occurred in only 25% of such patients. IgG-class reticulin antibodies, on the other hand, were not specific for DH, as they occurred in similar frequencies in patients with pemphigoid and pemphigus and in normal subjects. IgA-class reticulin antibodies occurred primarily in those patients with DH who had high titers of endomysial antibodies. None of the 20 such patients who were negative for endomysial antibodies had IgA-class reticulin antibodies. These studies indicate the high degree of specificity and sensitivity of endomysial antibodies.
采用间接免疫荧光法对30名正常受试者、45名疱疹样皮炎（DH）患者、31名类天疱疮患者和30名天疱疮患者进行了IgG类和IgA类网状纤维抗体以及IgA类肌内膜抗体的研究。在正常饮食的DH患者中，65%存在肌内膜抗体，而在无麸质饮食的患者、其他疾病患者及正常对照中则不存在。IgA类网状纤维抗体是DH的疾病特异性抗体，仅在25%的此类患者中出现。另一方面，IgG类网状纤维抗体并非DH所特有，因为它们在类天疱疮和天疱疮患者以及正常受试者中的出现频率相似。IgA类网状纤维抗体主要出现在那些肌内膜抗体滴度高的DH患者中。20名肌内膜抗体阴性的此类患者均无IgA类网状纤维抗体。这些研究表明肌内膜抗体具有高度的特异性和敏感性。
