Kulkarni Rakesh, Kunwar Sundar, Mandavkar Rutuja, Jeong Jae-Hun, Lee Jihoon
Department of Electronic Engineering, College of Electronics and Information, Kwangwoon University, Nowon-gu, Seoul 01897, Korea.
Nanomaterials (Basel). 2020 Oct 15;10(10):2034. doi: 10.3390/nano10102034.
A super-porous hybrid platform can offer significantly increased number of reaction sites for the analytes and thus can offer advantages in the biosensor applications. In this work, a significantly improved sensitivity and selectivity of hydrogen peroxide (HO) detection is demonstrated by a super-porous hybrid CuO/Pt nanoparticle (NP) platform on Si substrate as the first demonstration. The super-porous hybrid platform is fabricated by a physiochemical approach combining the physical vapor deposition of Pt NPs and electrochemical deposition of super-porous CuO structures by adopting a dynamic hydrogen bubble technique. Under an optimized condition, the hybrid CuO/Pt biosensor demonstrates a very high sensitivity of 2205 µA/mM·cm and a low limit of detection (LOD) of 140 nM with a wide detection range of HO. This is meaningfully improved performance as compared to the previously reported CuO-based HO sensors as well as to the other metal oxide-based HO sensors. The hybrid CuO/Pt platform exhibits an excellent selectivity against other interfering molecules such as glucose, fructose, dopamine, sodium chloride and ascorbic acid. Due to the synergetic effect of highly porous CuO structures and underlying Pt NPs, the CuO/Pt architecture offers extremely abundant active sites for the HO reduction and electron transfer pathways.
一种超多孔混合平台可为分析物提供显著增加的反应位点数量，因此在生物传感器应用中具有优势。在本工作中，首次展示了基于硅衬底的超多孔混合氧化铜/铂纳米颗粒（NP）平台对过氧化氢（HO）检测具有显著提高的灵敏度和选择性。该超多孔混合平台是通过一种物理化学方法制备的，该方法结合了铂纳米颗粒的物理气相沉积和采用动态氢气泡技术的超多孔氧化铜结构的电化学沉积。在优化条件下，氧化铜/铂混合生物传感器对HO表现出2205 μA/mM·cm的极高灵敏度和140 nM的低检测限，检测范围宽。与先前报道的基于氧化铜的HO传感器以及其他基于金属氧化物的HO传感器相比，这是有意义的性能提升。氧化铜/铂混合平台对葡萄糖、果糖、多巴胺、氯化钠和抗坏血酸等其他干扰分子表现出优异的选择性。由于高度多孔的氧化铜结构和底层铂纳米颗粒的协同作用，氧化铜/铂结构为HO还原和电子转移途径提供了极其丰富的活性位点。
