Ishiwata Sayaki, Tomita Yasuhiro, Ishiwata Sugao, Narui Koji, Daida Hiroyuki, Kasai Takatoshi
Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
J Clin Med. 2020 Oct 15;9(10):3314. doi: 10.3390/jcm9103314.
Obstructive sleep apnea (OSA) is related to an increased risk of cardiovascular diseases, including coronary artery disease (CAD). We investigated the association between OSA and the severity of CAD by assessing coronary angiography findings. We retrospectively analyzed patients who underwent their first coronary angiography to evaluate CAD and polysomnography (PSG) to investigate the severity of OSA in our hospital from March 2002 to May 2015. The severity of CAD was determined based on coronary angiography findings using the SYNTAX score. The patients were divided into two groups according to the apnea-hypopnea index (AHI): mild OSA (AHI < 15/h) and moderate-to-severe OSA (AHI ≥ 15/h). Overall, 98 patients were enrolled. The SYNTAX score was significantly different between the two groups ( = 0.001). After adjustment for other risk factors, including age, sex, obesity, hypertension, hyperlipidemia, diabetes mellitus, smoking status, and family history of CAD, moderate-to-severe OSA significantly correlated to the SYNTAX score (partial correlations = 0.24, = 0.039). These results suggest that the severity of CAD is related to moderate-to-severe OSA.
阻塞性睡眠呼吸暂停（OSA）与心血管疾病风险增加相关，包括冠状动脉疾病（CAD）。我们通过评估冠状动脉造影结果来研究OSA与CAD严重程度之间的关联。我们回顾性分析了2002年3月至2015年5月期间在我院接受首次冠状动脉造影以评估CAD以及多导睡眠图（PSG）以调查OSA严重程度的患者。CAD的严重程度根据冠状动脉造影结果使用SYNTAX评分来确定。根据呼吸暂停低通气指数（AHI）将患者分为两组：轻度OSA（AHI < 15/h）和中度至重度OSA（AHI≥15/h）。总体而言，共纳入98例患者。两组之间的SYNTAX评分有显著差异（= 0.001）。在对包括年龄、性别、肥胖、高血压、高脂血症、糖尿病、吸烟状况和CAD家族史等其他危险因素进行调整后，中度至重度OSA与SYNTAX评分显著相关（偏相关系数= 0.24，= 0.039）。这些结果表明CAD的严重程度与中度至重度OSA有关。
