Palazon-Cabanes Ana, Palazon-Cabanes Begoña, Rubio-Velazquez Elena, Lopez-Bernal Maria Dolores, Garcia-Medina Jose Javier, Villegas-Perez Maria Paz
Department of Ophthalmology, General University Hospital Reina Sofia, 30003 Murcia, Spain.
Department of Neurology, University Hospital La Arrixaca, 30005 Murcia, Spain.
J Clin Med. 2020 Oct 15;9(10):3317. doi: 10.3390/jcm9103317.
Our aim was to provide, for the first time, reference thickness values for the SD-OCT posterior pole algorithm (PPA) available for Spectralis OCT device (Heidelberg Engineering, Heidelberg, Germany) and to analyze the correlations with age, gender and axial length. We recruited 300 eyes of 300 healthy Caucasian subjects between 18 and 84 years. By PPA, composed of 64 (8 × 8) cells, we analyzed the thickness of the following macular layers: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE), inner retina, outer retina and full retina. Mean ± SD, 1st, 5th, 95th percentiles were obtained for each cell at all macular layers. Significant negative correlations were found between age and thickness for most macular layers. The mean thickness of most macular layers was thicker for men than women, except for RNFL, OPL and RPE, with no gender differences. GCL, IPL and INL thicknesses positively correlated with axial length in central cells, and negatively in the cells near the optic disk. The mean RNFL thickness was positively associated with axial length. This is the first normative database for PPA. Age, gender and axial length should be taken into account when interpreting PPA results.
我们的目的是首次提供适用于Spectralis OCT设备（德国海德堡海德堡工程公司）的频域光学相干断层扫描后极部算法（PPA）的参考厚度值，并分析其与年龄、性别和眼轴长度的相关性。我们招募了300名年龄在18至84岁之间的健康白种人受试者的300只眼睛。通过由64个（8×8）细胞组成的PPA，我们分析了以下黄斑层的厚度：视网膜神经纤维层（RNFL）、神经节细胞层（GCL）、内网状层（IPL）、内核层（INL）、外网状层（OPL）、外核层（ONL）、视网膜色素上皮（RPE）、内视网膜、外视网膜和全视网膜。获取了所有黄斑层每个细胞的平均值±标准差、第1、第5、第95百分位数。大多数黄斑层的厚度与年龄之间存在显著负相关。除RNFL、OPL和RPE外，大多数黄斑层的平均厚度男性比女性厚，无性别差异。GCL、IPL和INL的厚度在中央细胞中与眼轴长度呈正相关，在视盘附近的细胞中呈负相关。平均RNFL厚度与眼轴长度呈正相关。这是第一个关于PPA的规范数据库。在解释PPA结果时应考虑年龄、性别和眼轴长度。
