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免疫功能正常儿童的眼眶毛霉病:危险因素、诊断和治疗方法的回顾。

Orbital mucormycosis in immunocompetent children; review of risk factors, diagnosis, and treatment approach.

机构信息

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Shiraz University of Medical Sciences, Namazi Hospital, 7193711351, Zand Ave, Shiraz, Iran.

出版信息

BMC Infect Dis. 2020 Oct 19;20(1):770. doi: 10.1186/s12879-020-05460-2.

DOI:10.1186/s12879-020-05460-2
PMID:33076815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7574198/
Abstract

BACKGROUND

Orbital mucormycosis is a rare but potentially severe and troublesome invasive fungal infection that could be occurred even in healthy individuals. The initial clinical presentation is similar to bacterial pre-septal or septal cellulitis, especially in early stages.

CASE PRESENTATION

Herein, we describe the successful management of a series of five cases presenting with orbital mucormycosis in previously healthy children.

CONCLUSIONS

Orbital mucormycosis is extremely rare in healthy children and maybe life-threatening when diagnosis delayed given a similar clinical presentation with bacterial septal cellulitis. Intravenous antifungal therapy with amphotericin B and timely surgical drainage is live-saving.

摘要

背景

眼眶毛霉菌病是一种罕见但潜在严重且麻烦的侵袭性真菌感染,即使在健康个体中也可能发生。最初的临床表现类似于细菌性眶隔前或眶隔后蜂窝织炎,尤其是在早期阶段。

病例介绍

本文描述了成功治疗五例先前健康的儿童眼眶毛霉菌病的情况。

结论

眼眶毛霉菌病在健康儿童中极为罕见,由于与细菌性眶隔蜂窝织炎相似的临床表现,诊断延迟可能会危及生命。静脉内使用两性霉素 B 进行抗真菌治疗和及时的手术引流是救命的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36b6/7574198/d9f500a49283/12879_2020_5460_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36b6/7574198/d9f500a49283/12879_2020_5460_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36b6/7574198/d9f500a49283/12879_2020_5460_Fig1_HTML.jpg

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本文引用的文献

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2
Non-sinonasal isolated facio-orbital mucormycosis - A case report.非鼻-鼻窦孤立性面-眶毛霉菌病 - 病例报告。
J Mycol Med. 2018 Sep;28(3):538-541. doi: 10.1016/j.mycmed.2018.05.003.
3
Mucormycosis in Iran: A six-year retrospective experience.伊朗的毛霉病:六年回顾性经验。
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):55-63. doi: 10.1007/s12070-023-04077-6. Epub 2023 Jul 28.
4
Mucormycosis, New Causative Agents, and New Susceptible Populations: Review of Cases in a Tertiary Care Hospital in Iran (2007-2021).毛霉菌病、新的病原体和新的易感人群:伊朗一家三级护理医院病例回顾(2007 - 2021年)
Iran J Public Health. 2023 Nov;52(11):2467-2473. doi: 10.18502/ijph.v52i11.14046.
5
Co-infection associated with SARS-CoV-2 and their management.与严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)相关的合并感染及其管理。
Future Sci OA. 2023 Feb 3;8(9):FSO819. doi: 10.2144/fsoa-2022-0011. eCollection 2022 Oct.
6
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J Med Case Rep. 2022 Oct 31;16(1):400. doi: 10.1186/s13256-022-03594-2.
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Epidemiology, clinical features, therapeutic interventions and outcomes of mucormycosis in Shiraz: an 8-year retrospective case study with comparison between children and adults.设拉子的毛霉菌病的流行病学、临床特征、治疗干预和结局:一项 8 年回顾性病例研究,比较儿童和成人。
Sci Rep. 2022 Oct 13;12(1):17174. doi: 10.1038/s41598-022-21611-8.
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J Mycol Med. 2018 Jun;28(2):269-273. doi: 10.1016/j.mycmed.2018.02.014. Epub 2018 Mar 12.
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Methods Mol Biol. 2017;1508:17-65. doi: 10.1007/978-1-4939-6515-1_2.
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9
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Indian J Ophthalmol. 2016 May;64(5):337-45. doi: 10.4103/0301-4738.185588.
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Mycoses. 2016 Jul;59(7):402-15. doi: 10.1111/myc.12474. Epub 2016 Feb 15.