妊娠最后一天及长期妊娠后，大鼠胎儿棕色脂肪组织体内及分离的棕色脂肪细胞中脂肪生成的调节。
Regulation of rat foetal lipogenesis in brown adipose tissue in vivo and in isolated brown adipocytes during the last day of, and after prolonged, gestation.
作者信息
Roncero C, Lorenzo M, Benito M
出版信息
Biochem J. 1987 Apr 15;243(2):617-20. doi: 10.1042/bj2430617.
Abstract
Rates of lipogenesis in foetal isolated brown adipocytes from 22-day-pregnant rats were significantly increased by lactate plus pyruvate as major substrates in the incubation medium, in comparison with the endogenous rates. Insulin stimulated foetal brown-adipocyte lipogenesis, and adrenaline or noradrenaline and isoprenaline decreased lipogenesis. Glucagon had no effect on the lipogenic rate in brown adipocytes. Progesterone administration to the mother significantly increased the rates of lipogenesis in brown adipose tissue and in isolated brown adipocytes from 22-day foetuses. Prolongation of gestation by progesterone to day 23 decreased the rates of brown-adipose-tissue lipogenesis in vivo and in isolated cells in the post-mature foetuses.
摘要
与内源性速率相比，在22天孕期大鼠的胎儿分离棕色脂肪细胞中，乳酸加丙酮酸作为孵育培养基中的主要底物时，脂肪生成速率显著增加。胰岛素刺激胎儿棕色脂肪细胞的脂肪生成，而肾上腺素、去甲肾上腺素和异丙肾上腺素则降低脂肪生成。胰高血糖素对棕色脂肪细胞的脂肪生成速率没有影响。给母体注射孕酮可显著提高棕色脂肪组织以及来自22天胎儿的分离棕色脂肪细胞中的脂肪生成速率。孕酮将妊娠期延长至第23天，会降低成熟后期胎儿体内棕色脂肪组织以及分离细胞中的脂肪生成速率。
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