在妊娠最后一天，催乳素和孕酮在体内及分离的肝细胞中对母体和胎儿大鼠肝脏脂肪生成调节中的作用。
The role of prolactin and progesterone in the regulation of lipogenesis in maternal and foetal rat liver in vivo and in isolated hepatocytes during the last day of gestation.
作者信息
Lorenzo M, Roncero C, Benito M
出版信息
Biochem J. 1986 Oct 1;239(1):135-9. doi: 10.1042/bj2390135.
Abstract
The administration of progesterone on day 21 of gestation increases the rates of lipogenesis in the liver in vivo and in hepatocytes isolated from rats on day 22 of pregnancy. Bromocriptine administration increases the rates of hepatic lipogenesis in vivo, but has no effect on lipid synthesis in hepatocytes under the same treatment conditions. Concurrently, the administration of progesterone or bromocriptine on day 21 to the mother increases the rates of lipogenesis in the foetal liver in vivo on day 22. The rates of lipid synthesis in foetal isolated hepatocytes are increased by progesterone administration, but remain unchanged by bromocriptine.
摘要
在妊娠第21天给予孕酮可提高体内肝脏以及从妊娠第22天大鼠分离出的肝细胞中的脂肪生成率。给予溴隐亭可提高体内肝脏脂肪生成率，但在相同处理条件下对肝细胞脂质合成无影响。同时，在第21天给母体给予孕酮或溴隐亭可提高第22天胎肝在体内的脂肪生成率。给予孕酮可提高胎儿分离肝细胞中的脂质合成率，但给予溴隐亭则无变化。
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