Ryu Min-Ji, Baek Eun-Ki, Kim Soyeon, Seong Chi Nam, Yang Inho, Lim Kyung-Min, Nam Sang-Jip
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.
Biomol Ther (Seoul). 2021 Jan 1;29(1):98-103. doi: 10.4062/biomolther.2020.064.
). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.
通过对质谱、紫外光谱和核磁共振光谱数据的解析确定了其化学结构。安塔罗伊德是一种具有内酯和内酰胺部分的九元大环内酯。为了研究其在美白化妆品中的适用性，检测了其在B16F10小鼠黑色素瘤细胞中的抗黑色素生成活性。结果表明，安塔罗伊德对黑色素合成具有强烈的抑制活性，并且还减弱了α-黑素细胞刺激激素（α-MSH）诱导的树突形成。安塔罗伊德抑制了酪氨酸酶、TRP-1和TRP-2等黑色素生成酶的mRNA表达。这表明它可能作为黑色素生成的转录调节因子。总的来说，这种新型天然九元大环内酯的发现及其抗黑色素生成活性可能为美白剂的开发提供新的见解。
