Mokoena L, Alberts M, Tyobeka E
Biochem Biophys Res Commun. 1987 Aug 31;147(1):158-67. doi: 10.1016/s0006-291x(87)80101-8.
The effects of gluconeogenic hormones, adrenaline and cortisol, on insulin binding were studied in intact human red blood cells. Insulin binding was significantly decreased when red blood cells were preincubated with 1.0 microgram . ml-1 adrenaline or cortisol respectively. The Scatchard plot suggested that this was due to a decrease in surface receptor concentration. Furthermore, it showed that adrenaline also increased insulin receptor affinity. The negative co-operativity affinity profile demonstrated that adrenaline caused a rise in only the upper limit average affinity, Ki, of the insulin receptor.
在完整的人红细胞中研究了糖异生激素肾上腺素和皮质醇对胰岛素结合的影响。当红细胞分别与1.0微克·毫升⁻¹肾上腺素或皮质醇预孵育时，胰岛素结合显著降低。Scatchard图表明，这是由于表面受体浓度降低所致。此外，结果显示肾上腺素还增加了胰岛素受体亲和力。负协同亲和力图谱表明，肾上腺素仅导致胰岛素受体的上限平均亲和力Ki升高。
