[意大利版库科普洛斯混合抑郁评定量表（KMDRS）在意大利情绪障碍患者样本中的验证]

[Validation of the Italian version of the Koukopoulos Mixed Depression Rating Scale (KMDRS) in an Italian sample of subjects with mood disorders].

作者信息

Koukopoulos Alexia Emilia, Simonetti Alessio, Janiri Delfina, De Chiara Lavinia, Kotzalidis Georgios D, Sani Gabriele

机构信息

Centro Lucio Bini, Roma - Azienda Ospedaliera Universitaria Policlinico Umberto I, Sapienza Università di Roma.

Centro Lucio Bini, Roma - Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA - Dipartimento di Neurologia e Psichiatria, Sapienza Università di Roma.

出版信息

Riv Psichiatr. 2020 Sep-Oct;55(5):281-291. doi: 10.1708/3457.34460.

DOI:10.1708/3457.34460

PMID:33078020

Abstract

BACKGROUND

The construct of mixed depression (MxD), namely the simultaneous presence of excitatory symptoms during a depressive episode, has gained increased interest in the recent years. The Koukopoulos Mixed Depression Rating Scale (KMDRS) has been recently validated for the diagnosis and assessment of MxD. The aim of this study was to validate the Italian version of the KMDRS.

METHODS

Patients with a major depressive episode (MDE) (N=396, age, mean=44.73 years, SD=15.93) were recruited at Lucio Bini Center, Rome, Italy. All participants were administered the Italian version of the KMDRS, the Montgomery-Åsberg Depression Rating Scale (MADRS), the Young Mania Rating Scale (YMRS), the Clinical Global Impressions (CGI), and the Global Assessment of Functioning (GAF). We calculated predictive validity, and performed Receiver Operator Curve (ROC) analysis, Cronbach's alpha, and inter-rater reliability.

RESULTS

Predictive validity (C-statistic= 0.80; IC 95%: 0.75, 0.85) and capacity [OR=1.25±.03 (SE); 95% CI: 1.18, 1.32; p<.001] were good, matching those of the original version, whereas internal consistency (Cronbach's alpha = .70, IC 95%: 0.65, 0.75) and interrater reliability (Cohen's kappa= 0.74) were adequate.

CONCLUSIONS

The agreement of results with those of the original version point to the validity of the Italian version of KMDRS in assessing MxD.

摘要

背景

混合性抑郁（MxD）这一概念，即在抑郁发作期间同时存在兴奋性症状，近年来受到了越来越多的关注。库科波洛斯混合性抑郁评定量表（KMDRS）最近已被验证可用于MxD的诊断和评估。本研究的目的是验证KMDRS的意大利语版本。

方法

在意大利罗马的卢西奥·比尼中心招募了患有重度抑郁发作（MDE）的患者（N = 396，年龄，平均 = 44.73岁，标准差 = 15.93）。所有参与者均接受了KMDRS意大利语版本、蒙哥马利-阿斯伯格抑郁评定量表（MADRS）、杨氏躁狂评定量表（YMRS）、临床总体印象（CGI）和功能总体评定量表（GAF）的测试。我们计算了预测效度，并进行了受试者工作特征曲线（ROC）分析、克朗巴赫α系数分析和评分者间信度分析。

结果

预测效度（C统计量 = 0.80；95%置信区间：0.75，0.85）和能力[比值比 = 1.25±.03（标准误）；95%置信区间：1.18，1.32；p <.001]良好，与原始版本相当，而内部一致性（克朗巴赫α系数 = 0.70，95%置信区间：0.65，0.75）和评分者间信度（科恩kappa系数 = 0.74）足够。