Rincón-López Juliana, Almanza-Arjona Yara C, Riascos Alejandro P, Rojas-Aguirre Yareli
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, 04510, Mexico City, Mexico.
Instituto de Ciencias Aplicadas y Tecnología, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, 04510, Mexico City, Mexico.
J Drug Deliv Sci Technol. 2021 Feb;61:102156. doi: 10.1016/j.jddst.2020.102156. Epub 2020 Oct 14.
We herein disclose how global cyclodextrin-based pharmaceutical technologies have evolved since the early 80s through a 1998 patents dataset retrieved from Derwent Innovation Index. We used text-mining techniques based on the patents semantic content to extract the knowledge contained therein, to analyze technologies related to the principal attributes of CDs: solubility, stability, and taste-masking enhancement. The majority of CDs pharmaceutical technologies are directed toward parenteral aqueous solutions. The development of oral and ocular formulations is rapidly growing, while technologies for nasal and pulmonary routes are emerging and seem to be promising. Formulations for topical, transdermal, vaginal, and rectal routes do not account for a high number of patents, but they may be hiding a great potential, representing opportunity research areas. Certainly, the progress in materials sciences, supramolecular chemistry, and nanotechnology, will influence the trend of that, apparently neglected, research. The bottom line, CDs pharmaceutical technologies are still increasing, and this trend is expected to continue in the coming years. Patent monitoring allows the identification of relevant technologies and trends to prioritize research, development, and investment in both, academia and industry. We expect the scope of this approach to be applied in the pharmaceutical field beyond CDs technological applications.
我们在此通过从德温特创新索引中检索到的1998年专利数据集，揭示了自80年代初以来基于环糊精的全球制药技术是如何发展的。我们使用基于专利语义内容的文本挖掘技术来提取其中包含的知识，以分析与环糊精主要特性相关的技术：溶解性、稳定性和掩味增强。大多数环糊精制药技术针对的是肠胃外水溶液。口服和眼部制剂的开发正在迅速增长，而鼻腔和肺部给药途径的技术正在兴起且似乎很有前景。局部、透皮、阴道和直肠给药途径的制剂专利数量不多，但它们可能隐藏着巨大潜力，代表着机会研究领域。当然，材料科学、超分子化学和纳米技术的进展将影响这一明显被忽视的研究趋势。归根结底，环糊精制药技术仍在增加，预计这一趋势在未来几年将持续。专利监测有助于识别相关技术和趋势，从而在学术界和工业界对研究、开发和投资进行优先排序。我们期望这种方法的应用范围能够扩展到环糊精技术应用之外的制药领域。
