Centre for Neurodegeneration and Neuroinflammation, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.
Department of Neurology and Neurosciences, Clínica Universidad de Navarra, Pamplona-Madrid, Spain.
J Neural Transm (Vienna). 2021 Jan;128(1):15-25. doi: 10.1007/s00702-020-02271-2. Epub 2020 Oct 20.
In these present studies, in vivo and and post-mortem studies have investigated the association between iron and inflammation. Early-stage Parkinson's disease (PD) patients, of less than 5 years disease duration, showed associations of plasmatic ferritin concentrations with both proinflammatory cytokine interleukin-6 and hepcidin, a regulator of iron metabolism as well as clinical measures. In addition ratios of plasmatic ferritin and iron accumulation in deep grey matter nuclei assessed with relaxometry T2* inversely correlated with disease severity and duration of PD. On the hand, post-mortem material of the substantia nigra compacta (SNc) divided according to Braak and Braak scores, III-IV and V-VI staging, exhibited comparable microgliosis, with a variety of phenotypes present. There was an association between the intensity of microgliosis and iron accumulation as assayed by Perl's staining in the SNc sections. In conclusion, markers of inflammation and iron metabolism in both systemic and brain systems are closely linked in PD, thus offering a potential biomarker for progression of the disease.
在这些目前的研究中，体内和死后研究调查了铁与炎症之间的关联。疾病持续时间少于 5 年的早期帕金森病 (PD) 患者表现出血浆铁蛋白浓度与促炎细胞因子白细胞介素-6 和铁调素之间的关联，铁调素是铁代谢的调节剂以及临床指标。此外，用弛豫测量法 T2* 评估的血浆铁蛋白与深部灰质核中铁积累的比值与 PD 的严重程度和持续时间呈负相关。另一方面，根据 Braak 和 Braak 评分、III-IV 和 V-VI 分期将致密部黑质 (SNc) 的死后材料进行分组，显示出类似的小胶质细胞增生，存在多种表型。在 SNc 切片中通过 Perl 染色检测到的铁积累与小胶质细胞增生的强度之间存在关联。总之，PD 中系统和大脑系统的炎症和铁代谢标志物密切相关，因此为疾病的进展提供了潜在的生物标志物。
