Department of Neurology, Faculty Hospital, Constantine the Philosopher University, Špitálska 6, 94901, Nitra, Slovak Republic.
Central European Institute of Technology (CEITEC), Brain and Mind Research Programme, 625 00, Brno, Czech Republic.
J Neural Transm (Vienna). 2018 May;125(5):875-881. doi: 10.1007/s00702-018-1857-5. Epub 2018 Feb 12.
The objective of this study is to assess whether elevation of serum inflammatory markers levels may indicate the progression of clinical impairment in Parkinson's disease (PD) patients. In 47 PD patients, the serum levels of the C3 and C4 part of the complement and Interleukin-6 (IL-6) were measured. The results at baseline and after 2 years were correlated with scales measuring memory, depression, motor symptoms, and quality of life. Patients with higher levels of C3 and C4 at baseline had decreased quality of life, verbal ability, and memory. Patients with higher IL-6 at baseline showed worse depression scores at 2 years. Patients with persistently higher levels of C3 and C4 at 2 years had worse quality of life and memory ability. Uncorrected p values are reported due to the exploratory nature of the study. The results indicate an impact of inflammation on non-motor signs and quality of life in PD. The increase of levels of serum inflammatory biomarkers may indicate the progression of non-motor impairment in PD.
本研究旨在评估血清炎症标志物水平升高是否可能预示帕金森病（PD）患者临床损害的进展。在 47 名 PD 患者中，测量了补体 C3 和 C4 部分以及白细胞介素 6（IL-6）的血清水平。基线时和 2 年后的结果与评估记忆、抑郁、运动症状和生活质量的量表相关。基线时 C3 和 C4 水平较高的患者生活质量、语言能力和记忆力下降。基线时 IL-6 水平较高的患者在 2 年后抑郁评分更差。2 年后 C3 和 C4 水平持续升高的患者生活质量和记忆力更差。由于研究的探索性质，报告了未校正的 p 值。结果表明炎症对 PD 的非运动症状和生活质量有影响。血清炎症生物标志物水平的升高可能表明 PD 中非运动性损害的进展。
