Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minami-koshigaya, Koshigaya, Saitama, 343-8555, Japan.
Endoscopy Center, Dokkyo Medical University Saitama Medical center, 2-1-50 Minami-koshigaya, Koshigaya, Saitama, 343-8555, Japan.
Clin J Gastroenterol. 2021 Feb;14(1):123-128. doi: 10.1007/s12328-020-01268-4. Epub 2020 Oct 20.
A 43-year-old Japanese man diagnosed with Cronkhite-Canada Syndrome (CCS) underwent endoscopic submucosal dissection for Helicobacter pylori-negative gastric cancer. Histologically, the completely resected specimen showed large and small irregular glands composed of foveolar epithelial-like atypical cells, and it was immunohistochemically MUC5AC positive overall, MUC6 positive except for the surface layer and nearby parts, and MUC2 negative. The patient was diagnosed with gastric-phenotype, low-grade, well-differentiated adenocarcinoma. This is a case of gastric cancer developing in CCS definitively without H. pylori infection. We conclude that H. pylori infection is not an absolute condition in gastric cancer associated with CCS. Elucidation of the true malignant potential of CCS excluding the effects of H. pylori infection is needed.
一位 43 岁的日本男性被诊断患有 Cronkhite-Canada 综合征（CCS），因幽门螺杆菌阴性胃癌接受内镜黏膜下剥离术。组织学上，完全切除的标本显示由小凹上皮样非典型细胞组成的大和小的不规则腺体，免疫组织化学染色总体上 MUC5AC 阳性，MUC6 阳性，除表面层和附近部分外，MUC2 阴性。患者被诊断为胃表型、低级别、高分化腺癌。这是一例明确无幽门螺杆菌感染的 CCS 相关胃癌病例。我们得出结论，幽门螺杆菌感染不是 CCS 相关胃癌的绝对条件。需要阐明排除幽门螺杆菌感染影响的 CCS 的真正恶性潜能。
