Department of Breast Surgery, Shanxi Bethune Hospital, Taiyuan, Shanxi, China.
Asia Pac J Clin Oncol. 2021 Aug;17(4):321-329. doi: 10.1111/ajco.13484. Epub 2020 Oct 20.
Cancer-related cognitive impairment (CRCI) is a common complaint in breast cancer patients, especially related to chemotherapy. It is characterized as cognitive disorders in areas of memory, attention and executive function, which can negatively affect patients' quality of life and their ability to work. While various assessment methods of CRCI cause highly diverse results in CRCI-related studies. Currently, it is not clear how cerebral structure and function change in breast cancer patients and underlying mechanisms of developing CRCI are still undefined. Intervention research is limited. This article reviews the results of CRCI-related studies and research progress and discusses the advantages and limits of various methods. Besides, the mechanisms and intervention strategies are reviewed.
癌症相关认知障碍(CRCI)是乳腺癌患者常见的主诉,特别是与化疗相关。它的特征是在记忆、注意力和执行功能等领域的认知障碍,这可能会对患者的生活质量和工作能力产生负面影响。虽然 CRCI 的各种评估方法在 CRCI 相关研究中导致结果高度多样化,但目前尚不清楚乳腺癌患者的大脑结构和功能如何变化,以及 CRCI 发展的潜在机制仍未确定。干预研究有限。本文综述了 CRCI 相关研究的结果和研究进展,并讨论了各种方法的优缺点。此外,还回顾了其机制和干预策略。