Von Ah Diane, Rio Carielle Joy, Carter Allie, Perkins Susan M, Stevens Erin, Rosko Ashley, Davenport Ashley, Kalady Mathew, Noonan Anne M, Crouch Adele, Storey Susan, Overcash Janine, Han Claire J, Yang Yesol, Li Haiying, Saligan Leorey N
College of Nursing, The Ohio State University, 394 Newton Hall, 1585 Neil Avenue, Columbus, OH 43210, USA.
Symptoms Biology Unit, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, 3 Center Drive, Bethesda, MD 20892, USA.
Cancers (Basel). 2024 Jul 31;16(15):2718. doi: 10.3390/cancers16152718.
Older cancer survivors in general are at greater risk for cancer-related cognitive impairment (CRCI), yet few studies have explored its association with health outcomes. This study examined the association between subjective and objective measures of cognitive function and physical function, frailty, and quality of life (QoL) among older breast cancer survivors.
Older breast cancer survivors who reported cognitive concerns completed surveys on patient-reported cognitive function, physical function, frailty, and QoL as well as objective tests of visuospatial working memory and sustained attention. Data were analyzed using descriptive statistics and separate linear regression models.
A total of 219 female breast cancer survivors completed the study. Perceived cognitive abilities were associated with better physical function, frailty, and QoL ( ≤ 0.001) while cognitive concerns were negatively related with these metrics ( ≤ 0.001). Poorer visuospatial working memory and sustained attention were linked to increased frailty ( ≤ 0.001-0.01), whereas poorer sustained attention was associated with poorer physical function ( < 0.01).
Older breast cancer survivors with perceived cognitive impairment and poorer cognitive performance reported poorer physical functioning, increased frailty, and poorer QoL. These findings underscore the importance of assessing cognitive concerns and their associated outcomes in older breast cancer survivors.
一般而言，老年癌症幸存者患癌症相关认知障碍（CRCI）的风险更高，但很少有研究探讨其与健康结局的关联。本研究调查了老年乳腺癌幸存者认知功能的主观和客观测量指标与身体功能、衰弱及生活质量（QoL）之间的关联。
报告有认知问题的老年乳腺癌幸存者完成了关于患者报告的认知功能、身体功能、衰弱和生活质量的调查，以及视觉空间工作记忆和持续注意力的客观测试。使用描述性统计和单独的线性回归模型对数据进行分析。
共有219名女性乳腺癌幸存者完成了该研究。感知到的认知能力与更好的身体功能、衰弱状况和生活质量相关（≤0.001），而认知问题与这些指标呈负相关（≤0.001）。较差的视觉空间工作记忆和持续注意力与衰弱加剧相关（≤0.001 - 0.01），而较差的持续注意力与较差的身体功能相关（<0.01）。
认知功能有受损感知且认知表现较差的老年乳腺癌幸存者报告的身体功能较差、衰弱加剧且生活质量较差。这些发现强调了评估老年乳腺癌幸存者认知问题及其相关结局的重要性。
