Kellam A M
Whitchurch Hospital, Heath Park, Cardiff, Wales.
Br J Psychiatry. 1987 Jun;150:752-9. doi: 10.1192/bjp.150.6.752.
Because of its rarity, the neuroleptic malignant syndrome has been studied in a survey of the world literature. Similar conditions which occurred before the advent of neuroleptics have also been included, as they may indicate that the drugs are not totally to blame. It is also apparent that with modern treatments, the condition is not usually lethal. The implications of this for theories of dopaminergic disturbances underlying the mental illnesses involved are considered. An overall picture of the syndrome, its treatment and outcome, is presented from over 200 published references. The spread of recognition of the condition throughout the world and especially across linguistic barriers has been followed.
由于其罕见性，已对世界文献进行调查以研究抗精神病药物恶性综合征。在抗精神病药物出现之前发生的类似病症也被纳入其中，因为它们可能表明药物并非完全是罪魁祸首。同样明显的是，在现代治疗手段下，这种病症通常不会致命。文中考虑了这一点对涉及精神疾病的多巴胺能紊乱理论的影响。从200多篇已发表的参考文献中呈现了该综合征的整体情况、治疗方法及结果。文中还追踪了该病症在全球的认知传播情况，尤其是跨越语言障碍的传播情况。
