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长期暴露于中等浓度细颗粒物与老龄化社会特定病因死亡率的关系。

Long-term exposure to moderate fine particulate matter concentrations and cause-specific mortality in an ageing society.

机构信息

Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.

出版信息

Int J Epidemiol. 2021 Jan 23;49(6):1792-1801. doi: 10.1093/ije/dyaa146.

DOI:10.1093/ije/dyaa146
PMID:33079997
Abstract

BACKGROUND

Long-term exposure to particulate matter <2.5 μm in size (PM2.5) is considered a risk factor for premature death. However, only a few studies have been conducted in areas with moderate PM2.5 concentrations. Moreover, an ageing society may be more susceptible to environmental exposure and future burden of mortality due to PM2.5.

METHODS

This study estimates hazard ratios (HRs) for all-cause and cause-specific mortality from long-term exposure to moderate PM2.5 concentrations in the elderly populations of seven cities in South Korea. We also projected nationwide elderly mortality caused by long-term exposure to PM2.5, accounting for population ageing until 2045. Mortality in 1 720 230 elderly adults aged ≥65 years in 2008 was monitored across 2009-16 and linked to modelled PM2.5 concentrations.

RESULTS

A total of 421 100 deaths occurred in 2009-16, and the mean of annual PM2.5 concentration ranged between 21.1 and 31.9 μg/m3 in most regions. The overall HR for a 10 μg/m3 increase in a 36-month PM2.5 moving average was 1.024 (95% confidence intervals: 1.009, 1.039). We estimated that 11 833 all-cause nationwide elderly deaths were attributable to PM2.5 exposure. Annual death tolls may increase to 17 948 by 2045. However, if PM2.5 is reduced to 5 μg/m3 by 2045, the tolls may show a lower increase to 3646.

CONCLUSIONS

Long-term exposure to moderately high levels of PM2.5 was associated with increased mortality risk among the elderly. Thus, PM2.5 reduction in response to the projected ageing-associated mortality in South Korea is critical.

摘要

背景

长期暴露于粒径小于 2.5μm 的颗粒物(PM2.5)被认为是导致过早死亡的一个危险因素。然而,仅有少数研究在 PM2.5 浓度中等的地区进行。此外,由于 PM2.5,老龄化社会可能更容易受到环境暴露和未来死亡率的影响。

方法

本研究评估了韩国 7 个城市老年人群长期暴露于中等 PM2.5 浓度下全因和特定原因死亡率的危害比(HR)。我们还预测了由于长期暴露于 PM2.5 而导致的全国老年人群的死亡率,同时考虑了到 2045 年的人口老龄化情况。我们对 2008 年年龄在 65 岁及以上的 172 万 230 名老年人的死亡率进行了监测,并将其与模型化的 PM2.5 浓度进行了关联。

结果

2009-2016 年期间共有 42.11 万人死亡,大多数地区的年 PM2.5 浓度平均值在 21.1-31.9μg/m3 之间。36 个月 PM2.5 移动平均值每增加 10μg/m3,总体 HR 为 1.024(95%置信区间:1.009,1.039)。我们估计,有 11833 例全国范围内归因于 PM2.5 暴露的老年全因死亡。到 2045 年,每年的死亡人数可能会增加到 17948 人。然而,如果到 2045 年 PM2.5 降低到 5μg/m3,死亡人数的增加可能会更低,降至 3646 人。

结论

长期暴露于中等水平的 PM2.5 与老年人的死亡风险增加有关。因此,韩国需要采取措施降低 PM2.5,以应对与人口老龄化相关的预计死亡率的增加。

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