Long-term exposure to fine particulate matter and incident asthma among elderly adults.

RATIONALE

Although an association of fine particulate matter (PM) with asthma incidence has been assumed, there is insufficient evidence regarding the effect of long-term exposure to PM on incident asthma among elderly adults.

OBJECTIVES

This study aimed to investigate an association between long-term exposure to PM and incident asthma among elderly adults in South Korea.

METHODS

Adults ≥65 years of age (n = 1,220,645) who did not visit hospitals for asthma during a washout period (between 2008 and 2010) were followed up until 2016 using data from the National Health Insurance System in South Korea. Incident asthma was defined as the number of patients with a primary diagnostic code of asthma who visited hospitals more than twice. We linked the health data with district-level PM concentrations and estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for incident asthma after adjusting for potential confounders in time-varying Cox proportional hazard models.

MEASUREMENTS AND MAIN RESULTS

Over 5,942,256 person-years, 54,522 patients developed asthma, with an incidence of 9.2 cases/1000 person-years. A 10 μg/m increase in the 36-month mean PM concentration was significantly associated with a 9% increase in incident asthma (HR = 1.09, 95% CI: 1.04-1.14). This association was found to be robust for different definitions of incident asthma and washout periods.

CONCLUSION

Long-term exposure to PM was associated with the incidence of asthma in elderly adults. This finding provides evidence of an association between PM and adult-onset asthma.