Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Universidad Tecnologica Nacional, Facultad Regional San Nicolas, San Nicolas, Argentina.
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Int J Public Health. 2024 Sep 27;69:1607683. doi: 10.3389/ijph.2024.1607683. eCollection 2024.
For the development of the 2021 global air quality guidelines, the World Health Organization (WHO) commissioned a series of systematic reviews and meta-analyses to assess the association between exposure to air pollution and all-cause and cause-specific mortality. One of these reviews, which we aim to update, focused on the effects of long-term exposure to PM and PM on all-cause and cause-specific mortality.
The protocol for this study was registered in PROSPERO (CRD42023425327). We searched the PubMed and Embase databases for studies published between September 2018 and May 2023. Study-specific effects were pooled using random-effects models.
We included 106 studies in the meta-analysis, 46 studies from the previous review and 60 from this update. All exposure-outcome pairs analysed showed positive and significant associations, except for PM and cerebrovascular mortality. The certainty of the evidence was rated as high for the majority of exposure-outcome pairs.
We included a large number of new cohorts, and provided new concentration-response functions that will inform WHO advice on the use of this information for air pollution health risk assessments.
为制定 2021 年全球空气质量准则，世界卫生组织（世卫组织）委托开展了一系列系统评价和荟萃分析，以评估接触空气污染与全因和特定原因死亡率之间的关系。我们旨在更新的其中一项评价侧重于长期接触 PM2.5 和 PM10 与全因和特定原因死亡率的影响。
本研究的方案已在 PROSPERO（CRD42023425327）中注册。我们在 PubMed 和 Embase 数据库中检索了 2018 年 9 月至 2023 年 5 月期间发表的研究。使用随机效应模型汇总研究特异性效应。
我们将 106 项研究纳入荟萃分析，其中 46 项来自先前的综述，60 项来自本次更新。除 PM2.5 和脑血管死亡率外，分析的所有暴露-结局关联均呈阳性且具有统计学意义。大多数暴露-结局关联的证据确定性被评为高。
我们纳入了大量新队列，并提供了新的浓度-反应函数，这些信息将为世卫组织关于使用该信息进行空气污染健康风险评估的建议提供依据。
