高密度脂蛋白与炎症的相互作用：功能比浓度更重要！
Interaction between high-density lipoproteins and inflammation: Function matters more than concentration!
机构信息
Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany; Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany.
Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
出版信息
Adv Drug Deliv Rev. 2020;159:94-119. doi: 10.1016/j.addr.2020.10.006. Epub 2020 Oct 17.
High-density lipoprotein (HDL) plays an important role in lipid metabolism and especially contributes to the reverse cholesterol transport pathway. Over recent years it has become clear that the effect of HDL on immune-modulation is not only dependent on HDL concentration but also and perhaps even more so on HDL function. This review will provide a concise general introduction to HDL followed by an overview of post-translational modifications of HDL and a detailed overview of the role of HDL in inflammatory diseases. The clinical potential of HDL and its main apolipoprotein constituent, apoA-I, is also addressed in this context. Finally, some conclusions and remarks that are important for future HDL-based research and further development of HDL-focused therapies are discussed.
高密度脂蛋白（HDL）在脂质代谢中起着重要作用，特别是有助于胆固醇逆转运途径。近年来，人们越来越清楚地认识到，HDL 对免疫调节的影响不仅取决于 HDL 浓度，而且可能更取决于 HDL 功能。本综述将简要介绍 HDL，然后概述 HDL 的翻译后修饰，并详细介绍 HDL 在炎症性疾病中的作用。在这方面，还讨论了 HDL 的临床潜力及其主要载脂蛋白成分 apoA-I。最后，讨论了一些对未来基于 HDL 的研究和进一步开发以 HDL 为重点的治疗方法很重要的结论和注意事项。
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